ReviewEFORT open reviews2024
Long bone uninfected non-union: grafting techniques.
Review in EFORT open reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bone morphogenetic protein, platelet-rich plasma, and bone marrow aspiration concentrate in the treatment of bone delayed union or nonunion: a systematic review and network meta-analysis of randomized controlled trials.European journal of medical research · 2025Pooled it
- Timed Up-and-Go Test Using Instrumented Insoles to Monitor Tibial or Malleolar Fracture Healing in Patients With Healing Fractures or Nonunion: Longitudinal and Cross-Sectional Exploratory Study.JMIR mHealth and uHealth · 2026Article
- Development and Internal Evaluation of a Biomarker-Based Model for Preoperative Diagnosis of Infectious Nonunion.Orthopaedic surgery · 2026Article
- Treatment of humeral shaft nonunion by exchange intramedullary nailing and circumferential cortical strut allograft: the Sarcophagus technique.JSES reviews, reports, and techniques · 2026Article
- Patient-Specific Virtual Surgical Planning and In-House CAD-/CAM-Guided Vascularized Bone Flaps for Salvage Extremity Reconstruction: A Case Series.Bioengineering (Basel, Switzerland) · 2026Article
- IL-1β/EPAS1-Associated Ferroptotic Stress Impairs Skeletal Stem/Progenitor Cell Function in Inflammation-Associated Fracture Nonunion.Current issues in molecular biology · 2026Article
- Osteogenic effect of platelet-rich fibrin on a bone defect model of long bone in rabbits.Joint diseases and related surgery · 2026Article
- [Comparison of effectiveness between infrapatellar and semi-extended parapatellar approaches for intramedullary nailing in treatment of type A tibial shaft fractures].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Severe methicillin-resistant Staphylococcus aureus (MRSA) sepsis with hematogenous pulmonary abscesses and humeral osteomyelitis in a previously healthy child: a case report.BMC infectious diseases · 2026Article
- Control Group Selection in Preclinical Rat Bone Defect Models: A Systematic Review.Journal of functional biomaterials · 2026Review
- Extra-Articular Distal Tibia Non-Union Treated With Ipsilateral Fibular Strut Graft with Implants In Situ - A Case Report.Journal of orthopaedic case reports · 2026Article
- Modern Approaches and Emerging Biological Therapies to Treat Fracture Nonunion.Pharmaceutics · 2025Review
- Screening and validation of autophagy-related mRNAs and lncRNAs in bone nonunion based on transcriptome sequencing analysis.Human cell · 2025Article
- Nonunion in Long Bone Fractures: A Comprehensive Review of Current Treatment Strategies.Cureus · 2025Review
- MiR-376a-3p inhibits bone repair by regulating osteoblastic differentiation.Journal of orthopaedic surgery and research · 2025Article
- The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration.Stem cell research & therapy · 2025Review
- Distal femoral bone defect treatment using an engineered hydroxyapatite cylinder scaffold made from rattan wood.BMJ case reports · 2025Article
- Enhancement of In Vivo Bone Regeneration by the Carbohydrate Derivative DP2.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long bone non-unions represent a serious clinical and socioeconomical problem due to the prolonged episodes, frequent sequelae, and variable treatment effectiveness. Bone grafts, classically involving the autologous iliac crest graft as the 'gold standard' bone graft, enhance bone regeneration and fracture healing incorporating osteoconductive and/or osteoinductive/osteogenic capacity to the non-union under treatment. Structural alternatives to autologous bone grafts include allografts and bone substitutes, expanding the available stock but loosing biological properties associated with cells in the graft. Biological alternatives to autologous bone grafts include bone marrow concentration from iliac crest aspiration, bone marrow aspiration from reaming of the diaphyseal medullary canal in the long bones, and isolated, expanded mesenchymal stem cells under investigation. When the combination with natural and synthetic bone substitutes allows for larger volumes of structural grafts, the enhancement of the biological regenerative properties through the incorporation of cells and their secretoma permits to foresee new bone grafting solutions and techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.