Evidence map›Paper›PMID 38726888›Full record

ArticleHuman brain mapping2024

In vivo disentanglement of diffusion frequency-dependence, tensor shape, and relaxation using multidimensional MRI.

Jessica T E Johnson, M Okan Irfanoglu, Eppu Manninen, Thomas J Ross, Yihong Yang, Frederik B Laun, Jan Martin, Daniel Topgaard, Dan Benjamini

Abstract read
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026
    Article
  2. Magnetic resonance imaging.Science advances · 2026
    Review
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4 · The record

Corrections and comments

  • Update of
    2023
5 · Who and what money

Authors and funding

9 authors.

Jessica T E JohnsonMultiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, Maryland, USA.
M Okan IrfanogluQuantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Eppu ManninenMultiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Thomas J RossNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
Yihong YangNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
Frederik B LaunInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Jan MartinDepartment of Chemistry, Lund University, Lund, Sweden.
Daniel TopgaardDepartment of Chemistry, Lund University, Lund, Sweden.
Dan BenjaminiMultiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, Maryland, USA.ORCID 0000-0002-9558-7056

Funding

Processing and Analysis of Quantitative Diffusion MRI DataZIAEB000088 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI PIERPAOLI, CARLO · 2023 to 2025
$2.2M
NIA NIH HHSNIDA NIH HHS
6 · The paper itself

Abstract

Diffusion MRI with free gradient waveforms, combined with simultaneous relaxation encoding, referred to as multidimensional MRI (MD-MRI), offers microstructural specificity in complex biological tissue. This approach delivers intravoxel information about the microstructure, local chemical composition, and importantly, how these properties are coupled within heterogeneous tissue containing multiple microenvironments. Recent theoretical advances incorporated diffusion time dependency and integrated MD-MRI with concepts from oscillating gradients. This framework probes the diffusion frequency,

Indexed as

Image Processing, Computer-AssistedAdultBrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansMaleYoung Adultdenoisingdiffusion‐relaxationdiffusion tensor distributiondiffusion time dependencyhuman brain

Identifiers

PMID38726888
PMCPMC11082920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.