Evidence map›Paper›PMID 38726710›Full record

SynthesisJournal of the American Medical Informatics Association : JAMIA2024

Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review.

Roger Lacson, Yufei Yu, Tsung-Ting Kuo, Lucila Ohno-Machado

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roger LacsonDepartment of Biomedical Informatics & Data Science, Yale School of Medicine, New Haven, CT 06510, United States.ORCID 0000-0002-9773-6457
Yufei YuDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA 92093, United States.ORCID 0000-0003-2068-5361
Tsung-Ting KuoDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA 92093, United States.ORCID 0000-0002-8728-4477
Lucila Ohno-MachadoDepartment of Biomedical Informatics & Data Science, Yale School of Medicine, New Haven, CT 06510, United States.ORCID 0000-0002-8005-7327

Funding

RADx-Rad Discoveries & Data: Consortium Coordination Center Program OrganizationU24LM013755 · NLM · YALE UNIVERSITY · PI ARONOFF-SPENCER, ELIAH S, OHNO-MACHADO, LUCILA · 2021 to 2023
$23.3M
Genetic & Social Determinants of Health: Center for Admixture Science and TechnologyRM1HG011558 · NHGRI · YALE UNIVERSITY · PI FRAZER, KELLY A, GYMREK, MELISSA · 2021 to 2025
$11.2M
Ethics Core (FABRIC)U54HG012510 · NHGRI · YALE UNIVERSITY · PI MALIN, BRADLEY A. · 2022 to 2025
$11.2M
San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
iAGREE: A Multi-Center, Networked Patient Consent StudyR01HG011066 · NHGRI · YALE UNIVERSITY · PI OHNO-MACHADO, LUCILA · 2020 to 2024
$4.2M
SOCAL: Privacy-protecting Sharing Of Clinical Data Across LaboratoriesR01EB031030 · NIBIB · YALE UNIVERSITY · PI KUO, TSUNG-TING · 2022 to 2025
$1.3M
NHGRI NIH HHS R01 HG011066NHGRI NIH HHS RM1 HG011558NHGRI NIH HHS U54 HG012510NIBIB NIH HHS R01 EB031030NIH HHS R01HG011066NLM NIH HHS T15 LM011271NLM NIH HHS U24 LM013755
6 · The paper itself

Abstract

objectiveBlockchain has emerged as a potential data-sharing structure in healthcare because of its decentralization, immutability, and traceability. However, its use in the biomedical domain is yet to be investigated comprehensively, especially from the aspects of implementation and evaluation, by existing blockchain literature reviews. To address this, our review assesses blockchain applications implemented in practice and evaluated with quantitative metrics. MATERIALS AND

methodsThis systematic review adapts the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework to review biomedical blockchain papers published by August 2023 from 3 databases. Blockchain application, implementation, and evaluation metrics were collected and summarized.

resultsFollowing screening, 11 articles were included in this review. Articles spanned a range of biomedical applications including COVID-19 medical data sharing, decentralized internet of things (IoT) data storage, clinical trial management, biomedical certificate storage, electronic health record (EHR) data sharing, and distributed predictive model generation. Only one article demonstrated blockchain deployment at a medical facility. DISCUSSION: Ethereum was the most common blockchain platform. All but one implementation was developed with private network permissions. Also, 8 articles contained storage speed metrics and 6 contained query speed metrics. However, inconsistencies in presented metrics and the small number of articles included limit technological comparisons with each other.

conclusionWhile blockchain demonstrates feasibility for adoption in healthcare, it is not as popular as currently existing technologies for biomedical data management. Addressing implementation and evaluation factors will better showcase blockchain's practical benefits, enabling blockchain to have a significant impact on the health sector.

Indexed as

BlockchainCOVID-19HumansInformation Disseminationbiomedicalblockchainelectronic health recordsevaluationimplementation

Identifiers

PMID38726710
PMCPMC11105130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.