Evidence map›Paper›PMID 38726371›Full record

ArticleiScience2024

Human CD4

Nikhila S Bharadwaj, Nicholas A Zumwalde, Arvinder Kapur, Manish Patankar, Jenny E Gumperz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikhila S BharadwajDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53706, USA.
Nicholas A ZumwaldeDepartment of Genetics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53706, USA.
Arvinder KapurQIAGEN Sciences Inc., 19300 Germantown Road, Germantown, MD 20874, USA.
Manish PatankarDepartment of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53706, USA.
Jenny E GumperzDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53706, USA.

Funding

Mechanisms of iNKT cell anti-viral adjuvancyR01AI136500 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E. · 2018 to 2022
$1.9M
Development of iPSC-derived iNKT cells to promote hematopoietic engraftmentR21AI159042 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E., SLUKVIN, IGOR I. · 2022 to 2023
$428k
NIAID NIH HHS R01 AI136500NIAID NIH HHS R21 AI159042
6 · The paper itself

Abstract

The transition of naive T lymphocytes into antigenically activated effector cells is associated with a metabolic shift from oxidative phosphorylation to aerobic glycolysis. This shift facilitates production of the key anti-tumor cytokine interferon (IFN)-γ; however, an associated loss of mitochondrial efficiency in effector T cells ultimately limits anti-tumor immunity. Memory phenotype (MP) T cells are a newly recognized subset that arises through homeostatic activation signals following hematopoietic transplantation. We show here that human CD4

Indexed as

cell biologyimmunity

Identifiers

PMID38726371
PMCPMC11079467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.