Evidence map›Paper›PMID 38725910›Full record

ReviewRSC chemical biology2024

Genome-wide mapping of G-quadruplex DNA: a step-by-step guide to select the most effective method.

Silvia Galli, Gem Flint, Lucie Růžičková, Marco Di Antonio

Abstract readReview
In one paragraph

Review in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  20. Dominant and genome-wide formation of DNA:RNA hybrid G-quadruplexes in living yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Silvia GalliImperial College London, Chemistry Department, Molecular Science Research Hub 82 Wood Lane London UK m.di-antonio@imperial.ac.uk.ORCID https://orcid.org/0000-0002-3316-0161
Gem FlintImperial College London, Chemistry Department, Molecular Science Research Hub 82 Wood Lane London UK m.di-antonio@imperial.ac.uk.ORCID https://orcid.org/0000-0002-5552-6216
Lucie RůžičkováImperial College London, Chemistry Department, Molecular Science Research Hub 82 Wood Lane London UK m.di-antonio@imperial.ac.uk.ORCID https://orcid.org/0000-0002-9818-1369
Marco Di AntonioImperial College London, Chemistry Department, Molecular Science Research Hub 82 Wood Lane London UK m.di-antonio@imperial.ac.uk.ORCID https://orcid.org/0000-0002-7321-1867

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of methods that enabled genome-wide mapping of DNA G-quadruplex structures in chromatin has played a critical role in providing evidence to support the formation of these structures in living cells. Over the past decade, a variety of methods aimed at mapping G-quadruplexes have been reported in the literature. In this critical review, we have sought to provide a technical overview on the relative strengths and weaknesses of the genomics approaches currently available, offering step-by-step guidance to assessing experimental needs and selecting the most appropriate method to achieve effective genome-wide mapping of DNA G-quadruplexes.

Identifiers

PMID38725910
PMCPMC11078208

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.