Evidence map›Paper›PMID 38725869›Full record

ArticleApplied sciences (Basel, Switzerland)2024

Reproducibility in Radiomics: A Comparison of Feature Extraction Methods and Two Independent Datasets.

Hannah Mary T Thomas, Helen Y C Wang, Amal Joseph Varghese, Ellen M Donovan, Chris P South, Helen Saxby, Andrew Nisbet, Vineet Prakash, Balu Krishna Sasidharan, Simon Pradeep Pavamani and 4 more

Abstract read
In one paragraph

Article in Applied sciences (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Insights into radiomics: a comprehensive review for beginners.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hannah Mary T Thomas *Department of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.
Helen Y C Wang *Centre for Vision, Speech and Signal Processing, University of Surrey, Guildford GU2 7XH, UK.
Amal Joseph VargheseDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.ORCID https://orcid.org/0009-0000-2844-7611
Ellen M DonovanCentre for Vision, Speech and Signal Processing, University of Surrey, Guildford GU2 7XH, UK.
Chris P SouthDepartment of Medical Physics, Royal Surrey NHS Foundation Trust, Guildford GU2 7XX, UK.
Helen SaxbySt Luke's Cancer Centre, Royal Surrey NHS Foundation Trust, Guildford GU2 7XX, UK.
Andrew NisbetDepartment of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK.ORCID https://orcid.org/0000-0002-0652-808X
Vineet PrakashSt Luke's Cancer Centre, Royal Surrey NHS Foundation Trust, Guildford GU2 7XX, UK.
Balu Krishna SasidharanDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.ORCID https://orcid.org/0000-0002-2814-161X
Simon Pradeep PavamaniDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.
Devakumar DevadhasDepartment of Nuclear Medicine, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.
Manu MathewDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.
Rajesh Gunasingam IsiahDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India.
Philip M EvansCentre for Vision, Speech and Signal Processing, University of Surrey, Guildford GU2 7XH, UK.ORCID https://orcid.org/0000-0002-8102-6581

Funding

DBT-Wellcome Trust India Alliance IA/E/18/1/504306
6 · The paper itself

Abstract

Radiomics involves the extraction of information from medical images that are not visible to the human eye. There is evidence that these features can be used for treatment stratification and outcome prediction. However, there is much discussion about the reproducibility of results between different studies. This paper studies the reproducibility of CT texture features used in radiomics, comparing two feature extraction implementations, namely the MATLAB toolkit and Pyradiomics, when applied to independent datasets of CT scans of patients: (i) the open access RIDER dataset containing a set of repeat CT scans taken 15 min apart for 31 patients (RIDER Scan 1 and Scan 2, respectively) treated for lung cancer; and (ii) the open access HN1 dataset containing 137 patients treated for head and neck cancer. Gross tumor volume (GTV), manually outlined by an experienced observer available on both datasets, was used. The 43 common radiomics features available in MATLAB and Pyradiomics were calculated using two intensity-level quantization methods with and without an intensity threshold. Cases were ranked for each feature for all combinations of quantization parameters, and the Spearman's rank coefficient,

Indexed as

CT imaginghead and neck cancerlung cancerradiomicsrepeatabilityreproducibilityvalidation

Identifiers

PMID38725869
PMCPMC7615943

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.