Evidence map›Paper›PMID 38725858›Full record

ArticleInternational journal of biological sciences2024

The dysadherin/FAK axis promotes individual cell migration in colon cancer.

Choong-Jae Lee, Tae-Young Jang, Jee-Heun Kim, Songwon Lim, Sunjae Lee, Jeong-Seok Nam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Choong-Jae LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Tae-Young JangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Jee-Heun KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Songwon LimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Sunjae LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Jeong-Seok NamSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of cancer cell motility is a key driver of invasion and metastasis. High dysadherin expression in cancer cells is correlated with invasion and metastasis. Here, we found the molecular mechanism by which dysadherin regulates the migration and invasion of colon cancer (CC). Comprehensive analysis using single-cell RNA sequencing data from CC patients revealed that high dysadherin expression in cells is linked to cell migration-related gene signatures. We confirmed that the deletion of dysadherin in tumor cells hindered local invasion and distant migration using

Indexed as

Cell MovementColonic NeoplasmsFocal Adhesion Protein-Tyrosine KinasesIon ChannelsMicrofilament ProteinsAnimalsCell Line, TumorFocal Adhesion Kinase 1HumansMiceSignal TransductionFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesFXYD5 protein, humanIon ChannelsMicrofilament ProteinsPTK2 protein, humanActin dynamicsCell motilityDysadherinFAK.Focal adhesion

Identifiers

PMID38725858
PMCPMC11077383

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.