ReviewJournal of clinical and experimental dentistry2024
Update on chelating agents in endodontic treatment: A systematic review.
Review in Journal of clinical and experimental dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07241650 (Postoperative Pain and Quality of Life in Root Canal Treatment), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postoperative Pain and Quality of Life in Root Canal Treatment: Prospective Study
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping risk of bias criteria in systematic reviews of in vitro endodontic studies: an umbrella review.Evidence-based dentistry · 2025Pooled it
- Influence of continuous chelation on the push-out bond strength of epoxy resin and calcium silicate sealers in oval root canals.Clinical oral investigations · 2026Article
- Effects of Different Irrigation Protocols on the Surface Morphology and Elemental Composition of Super One File Nickel-Titanium Instruments.Bioengineering (Basel, Switzerland) · 2026Article
- Effects of Continuous Chelation with Etidronate on Mechanical Properties of the Root Canal Dentin: A Systematic Review with Meta-Analysis.Dentistry journal · 2026Review
- Article
- Evaluation of smear layer removal using polymer and metal tips of ultrasonic irrigation device: an in vitro study.BMC oral health · 2026Article
- Comparative evaluation of irrigation techniques on dentin nanohardness, flexural strength, and chemical composition: an in vitro study.Scientific reports · 2026Article
- Efficacy of Etidronic Acid for Smear Layer Removal: A Systematic Review of In Vitro Studies.Journal of functional biomaterials · 2026Review
- Smear layer removal by EDTA, citric acid, and maleic acid under five irrigant delivery and activation protocols: anFrontiers in dental medicine · 2026Article
- Clinical and Radiographic Outcomes of Root Canal Obturation with Hydraulic Condensation and Tricalcium Silicate Bioceramic Sealer: A 12-Month Observational Study on Periapical Healing.Journal of functional biomaterials · 2025Article
- Assessment of calcium ion loss and its effect on microhardness of root canal dentin using 1% phytic acid and 17% EDTA: AnJournal of conservative dentistry and endodontics · 2025Article
- Evaluation of Root Canal Cleaning and Irrigant Penetration Using Different Irrigation Protocols: A Combined SEM and Single-Tooth Micro-CT Study.Clinical and experimental dental research · 2025Article
- Radiographic and Clinical Outcomes of Laser-Enhanced Disinfection in Endodontic Therapy.Journal of clinical medicine · 2025Article
- Non-Surgical Management of Apical Fenestration Associated with Apical Periodontitis in a Tooth with an Open Apex: A Case Report.Reports (MDPI) · 2025Article
- Effects of phytic acid and etidronic acid using continuous and sequential chelation on the removal of smear layer, dentin microhardness, and push-out bond strength of calcium silicate-based cement.BMC oral health · 2025Article
- Comparative Evaluation of the Effect of EDTA, Chitosan, Etidronic Acid, and Silver Citrate on the Mineral Content of Root Canal Dentin Using Energy Dispersive X-ray Spectroscopy: An In-Vitro Study.European endodontic journal · 2025Article
- Comparative Accuracy and Reliability of Three Electronic Apex Locators in Determining the Apical Constriction of Molar Canals: A Micro-CT Evaluation.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim of this review was to assess the evidence regarding the most commonly used chelating agents in terms of efficacy, erosive potential, cytotoxicity, interaction, antimicrobial effect, impact on sealers adhesion, and release of growth factors. Material and Methods: MEDLINE (PubMed) database, Cochrane Library and Scopus were searched up to January 14, 2023, including studies with one or more of the following chelating agents: 17% EDTA, 9% and 18% HEDP, 10% and 20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid. In addition, the reference lists of all selected articles were also checked to identify additional relevant studies. Articles published in English and available in full-text were selected. The quality of studies was assessed using the modified CONSORT checklist guide and the Cochrane Collaboration tool. Results: The electronic search yielded 538 citations, 56 of which were included. The articles included had moderate and low evidence values. Among 56 articles included, 55 were in vitro studies and one was a randomized clinical trial. Among the in vitro studies, 15 evaluated efficacy and dentin erosion, 12 evaluated interaction with other endodontic irrigants, 9 tested antimicrobial effect, 4 evaluated cytotoxicity in hamster and rat lung cells, 9 evaluated intervention in adhesion of filling materials and 8 focused on release of growth factors and on behavior of stem cells in regenerative endodontic. The RCT tested antimicrobial effect. Conclusions: 17% EDTA is the most effective in smear layer removal and in releasing growth factors on regenerative endodontics. However, the current incorporation of 9% and 18% etidronic acid has shown optimal results due to its compatibility with sodium hypochlorite and its capability on avoiding smear layer formation through a continuous chelation action. Despite these preliminary findings, methodological standardization between studies is required and in vivo studies are necessary to confirm in vitro studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.