Evidence map›Paper›PMID 38725702›Full record

ArticleSouthern African journal of HIV medicine2024

Trends in body mass index in the pre-dolutegravir period in South Africa.

Florian van Ginkel, Roos E Barth, Hugo Tempelman, Kerstin Klipstein-Grobusch, Diederick E Grobbee, Karine Scheuermaier, Francois W D Venter, Alinda G Vos-Seda

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Article in Southern African journal of HIV medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Florian van GinkelJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-1025-3795
Roos E BarthDepartment of Infectious Disease, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-0123-3434
Hugo TempelmanNdlovu Care Group, Groblersdal, South Africa.ORCID https://orcid.org/0000-0001-6119-4003
Kerstin Klipstein-GrobuschJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-5462-9889
Diederick E GrobbeeJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-4472-4468
Karine ScheuermaierJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-3397-543X
Francois W D VenterDepartment of Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-6919-5171
Alinda G Vos-SedaJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-9551-6223

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antiretroviral therapy (ART) is associated with weight gain, but this has been shown to be more marked with dolutegravir and other integrase strand transfer inhibitors. Objectives: We studied weight gain in people living with HIV (PLWH) on ART compared to the general population in the period before dolutegravir was introduced in a rural South African cohort. Method: Longitudinal analysis of the Ndlovu Cohort Study including 36-48 months' follow-up data. From 2014 to 2019, data were collected annually in Limpopo, rural South Africa. Linear mixed models using HIV status, demographics, ART use and cardiovascular risk factors were used to estimate trends in body mass index (BMI) over time. Results: In total, 1518 adult, non-pregnant participants were included, of whom 518 were PLWH on ART (79.8%), 135 PLWH not yet on ART (20.2%) and 865 HIV-negative. HIV-negative participants had significantly higher BMIs than PLWH on ART at all study visits. There was a significant increase in BMI in all subgroups after 36 months (PLWH on ART, BMI +1.2 kg/m Conclusion: The increase in BMI in PLWH and HIV-negative participants is a serious warning signal as obesity results in morbidity and mortality.

Indexed as

antiretroviral therapybody mass indexHIVintegrase strand transfer inhibitorsobesitysub-Saharan Africa

Identifiers

PMID38725702
PMCPMC11079384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.