Evidence map›Paper›PMID 38725670›Full record

ArticleImmune network2024

Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice.

Jung Ah Kim, Sung-Hee Kim, Jeong Jin Kim, Hyuna Noh, Su-Bin Lee, Haengdueng Jeong, Jiseon Kim, Donghun Jeon, Jung Seon Seo, Dain On and 31 more

Abstract read
In one paragraph

Article in Immune network, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Jung Ah KimDepartment of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-1264-8328
Sung-Hee KimDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-2970-9449
Jeong Jin KimDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-8886-5441
Hyuna NohKorea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0003-4806-6730
Su-Bin LeeDepartment of Microbiology and Immunology and Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0009-0001-8023-5613
Haengdueng JeongDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-9218-7372
Jiseon KimDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-0979-0278
Donghun JeonDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-9161-6198
Jung Seon SeoDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0001-6238-6023
Dain OnKorea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-6227-2058
Suhyeon YoonKorea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-3883-8330
Sang Gyu LeeInterdisciplinary Program for Bioinformatics, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0001-5719-4035
Youn Woo LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0002-4559-1604
Hui Jeong JangDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0003-2019-6269
In Ho ParkDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-2190-5469
Jooyeon OhDepartment of Microbiology, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-1701-7792
Sang-Hyuk SeokDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24342, Korea.ORCID https://orcid.org/0000-0002-9213-8706
Yu Jin LeeDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24342, Korea.ORCID https://orcid.org/0000-0002-6386-5381
Seung-Min HongLaboratory of Avian Diseases, BK21 PLUS Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0001-5488-8445
Se-Hee AnLaboratory of Avian Diseases, BK21 PLUS Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-2206-1299
Joon-Yong BaeDepartment of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul 02842, Korea.ORCID https://orcid.org/0000-0002-2483-4208
Jung-Ah ChoiScience Unit, International Vaccine Institute, Seoul 08826, Korea.ORCID https://orcid.org/0000-0003-2381-7374
Seo Yeon KimPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0001-5178-2055
Young Been KimPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0003-4838-996X
Ji-Yeon HwangPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0003-4154-3012
Hyo-Jung LeeDepartment of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam 23620, Korea.ORCID https://orcid.org/0000-0002-4991-0705
Hong Bin KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 23620, Korea.ORCID https://orcid.org/0000-0001-6262-372X
Dae Gwin JeongBionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34242, Korea.ORCID https://orcid.org/0000-0002-0764-1404
Daesub SongDepartment of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-2759-1061
Manki SongScience Unit, International Vaccine Institute, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-8279-9041
Man-Seong ParkDepartment of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul 02842, Korea.ORCID https://orcid.org/0000-0002-7427-486X
Kang-Seuk ChoiLaboratory of Avian Diseases, BK21 PLUS Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0001-6825-6924
Jun Won ParkDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24342, Korea.ORCID https://orcid.org/0000-0003-4677-1786
Jun-Won YunLaboratory of Veterinary Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-0155-4190
Jeon-Soo ShinDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-8294-3234
Ho-Young LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0001-6518-0602
Ho-Keun KwonDepartment of Microbiology and Immunology and Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-3175-0376
Jun-Young SeoDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-4004-2013
Ki Taek NamDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0001-5292-1280
Heon Yung GeeDepartment of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-8741-6177
Je Kyung SeongKorea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0003-1177-6958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of coronavirus disease 2019. In this study, we examined the effects of viral doses on the lung and spleen of K18-hACE2 transgenic mice by temporal histological and transcriptional analyses. Approximately, 1×10

Indexed as

Dose-response relationship, immunologicImmune responseK18-hACE2 miceSARS-CoV-2Transcriptome profiling

Identifiers

PMID38725670
PMCPMC11076298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.