ArticleChemical science2024
Easy access to polyhalogenated biaryls: regioselective (di)halogenation of hypervalent bromines and chlorines.
Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synthesis, Structure, and Reactivity of Hypervalent Iodine Reagents Stabilized by Internal Out-of-Plane Halogen Bonding:The Journal of organic chemistry · 2026Article
- Syntheses of 2,2'-dihalo-1,1'-binaphthyl compounds via palladium-catalysed 1,2-halo shift-cyclisation coupling reaction of α-hydroxyl haloalkynes.Nature communications · 2026Article
- Bacterial cytochrome P450 for oxidative halogenated biaryl coupling.ACS catalysis · 2026Article
- Electrochemical synthesis of cyclic biaryl λBeilstein journal of organic chemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyhalogenated biaryls are unique motifs offering untapped potential as versatile building blocks for the expedient synthesis of complex biaryl compounds. Overcoming the limitations of conventional syntheses, we introduce a novel, metal-free, operationally simple and one-pot approach to regioselectively (di)halogenate biaryl compounds under mild conditions using cyclic biaryl hypervalent bromine and chlorine substrates as masked arynes. Through chemoselective post-functionalizations, these valuable products can expand the toolbox for synthesizing biaryl-containing scaffolds, addressing a critical gap in the field.
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Registered trials
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