Evidence map›Paper›PMID 38725429›Full record

ArticleJournal of periodontal & implant science2024

Osteogenic potential of Frondoside A in human periodontal ligament cells: an RNA-Seq analysis.

Young Kim, Si-Won Kang, Ju Ri Ye, Seong Eun Kim, Yong Kwon Chae, Ok Hyung Nam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal & implant science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Young KimDepartment of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea.ORCID https://orcid.org/0000-0003-4991-8704
Si-Won KangDepartment of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea.ORCID https://orcid.org/0009-0002-3378-158X
Ju Ri YeDepartment of Dentistry, Graduate School, Kyung Hee University, Seoul, Korea.ORCID https://orcid.org/0000-0003-4278-5566
Seong Eun KimInterdisciplinary Program of Biomedical Engineering, Graduate School, Chonnam National University, Gwangju, Korea.ORCID https://orcid.org/0009-0004-5091-5732
Yong Kwon ChaeDepartment of Pediatric Dentistry, Kyung Hee University, College of Dentistry, Kyung Hee University Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-8059-9305
Ok Hyung NamDepartment of Pediatric Dentistry, Kyung Hee University, College of Dentistry, Kyung Hee University Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-6386-803X

Funding

National Research Foundation of Korea 2019R1A5A2027521National Research Foundation of Korea 2020R1C1C1006937National Research Foundation of Korea 2021R1C1C1009601
6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the effects of Frondoside A (FA) on the osteogenic differentiation of human periodontal ligament (PDL) cells.

methodsHuman PDL cells were cultured in osteogenic medium and treated with FA at concentrations of 0, 0.05, and 0.2 µM for 14 days. The expression levels of genes associated with osteogenic differentiation were assessed using quantitative real-time polymerase chain reaction analysis. Subsequently, RNA sequencing was performed to identify enriched gene sets following FA treatment. Alkaline phosphatase (ALP) activity was measured to confirm the osteogenic potential of FA.

resultsTreatment with 0.2 µM FA significantly increased the expression levels of runt-related transcription factor 2 (

conclusionsWithin the limitations of this study, FA treatment influenced periodontal regeneration by promoting the osteogenic differentiation of human PDL cells.

Indexed as

Frondoside AOsteogenesisPeriodontal ligamentPeriodontitis

Identifiers

PMID38725429
PMCPMC11729245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.