Evidence map›Paper›PMID 38725361›Full record

ArticleAge and ageing2024

Post-COVID-19 patients in geriatric rehabilitation substantially recover in daily functioning and quality of life.

Lisa S van Tol, Miriam L Haaksma, Matteo Cesari, Frances Dockery, Irma H J Everink, Bahaa N Francis, Adam L Gordon, Stefan Grund, Luba Matchekhina, Laura Monica Perez Bazan and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lisa S van TolDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9334-9214
Miriam L HaaksmaDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Matteo CesariIRCCS Istituti Clinici Maugeri, University of Milan, Milan, Italy.
Frances DockeryBeaumont Hospital & Royal College of Surgeons in Ireland, Dublin, Ireland.
Irma H J EverinkDepartment of Health Services Research, Maastricht University, Maastricht, The Netherlands.
Bahaa N FrancisFliman Geriatric Rehabilitation Hospital, Zalman Shneur Street, Haifa, 31021, Israel.
Adam L GordonAcademic Unit of Injury, Recovery and Inflammation Sciences (IRIS), School of Medicine, University of Nottingham, Medical School, Nottingham, NG7 2UH, UK.
Stefan GrundCenter for Geriatric Medicine, Agaplesion Bethanien Hospital Heidelberg, Geriatric Center at the Heidelberg University, Heidelberg, Germany.
Luba MatchekhinaRussian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University, Moscow, Russia.
Laura Monica Perez BazanRE-FiT Barcelona Research Group, Parc Sanitari Pere Virgili Hospital and Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.
Jos M G A ScholsDepartment of Health Services Research, Maastricht University, Maastricht, The Netherlands.
Eva TopinkováDepartment of Geriatrics, First Faculty of Medicine, Charles University and General Faculty Hospital, Prague, Czech Republic.
Mark A VassalloKarin Grech Hospital, Pieta, Malta.
Monique A A CaljouwDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2550-530X
Wilco P AchterbergDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9227-7135
EU-COGER consortium

Funding

Leiden University Fund LEF2106-2-47UK National Institute of Health Research Academic Research Collaboration-East MidlandsUniversity Network of the Care sector South-Holland 640001003Zorg Onderzoek Nederland en Medische Wetenschappen 10430102110005
6 · The paper itself

Abstract

backgroundAfter an acute infection, older persons may benefit from geriatric rehabilitation (GR).

objectivesThis study describes the recovery trajectories of post-COVID-19 patients undergoing GR and explores whether frailty is associated with recovery.

designMulticentre prospective cohort study.

setting59 GR facilities in 10 European countries.

participantsPost-COVID-19 patients admitted to GR between October 2020 and October 2021.

methodsPatients' characteristics, daily functioning (Barthel index; BI), quality of life (QoL; EQ-5D-5L) and frailty (Clinical Frailty Scale; CFS) were collected at admission, discharge, 6 weeks and 6 months after discharge. We used linear mixed models to examine the trajectories of daily functioning and QoL.

results723 participants were included with a mean age of 75 (SD: 9.91) years. Most participants were pre-frail to frail (median [interquartile range] CFS 6.0 [5.0-7.0]) at admission. After admission, the BI first steeply increased from 11.31 with 2.51 (SE 0.15, P < 0.001) points per month and stabilised around 17.0 (quadratic slope: -0.26, SE 0.02, P < 0.001). Similarly, EQ-5D-5L first steeply increased from 0.569 with 0.126 points per month (SE 0.008, P < 0.001) and stabilised around 0.8 (quadratic slope: -0.014, SE 0.001, P < 0.001). Functional recovery rates were independent of frailty level at admission. QoL was lower at admission for frailer participants, but increased faster, stabilising at almost equal QoL values for frail, pre-frail and fit patients.

conclusionsPost-COVID-19 patients admitted to GR showed substantial recovery in daily functioning and QoL. Frailty at GR admission was not associated with recovery and should not be a reason to exclude patients from GR.

Indexed as

Activities of Daily LivingCOVID-19Frail ElderlyFrailtyGeriatric AssessmentQuality of LifeRecovery of FunctionAgedAged, 80 and overEuropeFemaleHumansMaleProspective StudiesSARS-CoV-2COVID-19geriatric rehabilitationolder peoplerecovery

Identifiers

PMID38725361
PMCPMC11082471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.