Evidence map›Paper›PMID 38725026›Full record

Observational studyAntimicrobial resistance and infection control2024

Impact of COVID-19 on antimicrobial stewardship activities in Italy: a region-wide assessment.

Costanza Vicentini, Silvia Corcione, Giuseppina Lo Moro, Alessandro Mara, Francesco Giuseppe De Rosa, Carla Maria Zotti, collaborating group “Unità Prevenzione Rischio Infettivo (UPRI), Regione Piemonte”

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial resistance and infection control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Costanza VicentiniDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, Turin, 10126, Italy. costanza.vicentini@unito.it.
Silvia CorcioneDepartment of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy.
Giuseppina Lo MoroDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, Turin, 10126, Italy.
Alessandro MaraDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, Turin, 10126, Italy.
Francesco Giuseppe De RosaDepartment of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy.
Carla Maria ZottiDepartment of Public Health and Pediatrics, University of Turin, Via Santena 5 bis, Turin, 10126, Italy.
collaborating group “Unità Prevenzione Rischio Infettivo (UPRI), Regione Piemonte”

Funding

MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases Project no. PE00000007, INF-ACT
6 · The paper itself

Abstract

backgroundIn the region of Piedmont, in Northern Italy, formal monitoring of antimicrobial stewardship (AMS) programs has been in place since 2012. The objective of our study was to provide an updated assessment of AMS programs operating in our region, and to assess the impact of the COVID-19 pandemic on stewardship activities.

methodsA retrospective observational study was conducted to investigate AMS programs implemented in acute-care trusts participating in a broader healthcare-associated infections and antimicrobial resistance (AMR) prevention and control program, promoted by the regional health department. Within this program, structure, process, and outcome indicators of AMS programs were investigated, using a previously developed scoring system. Differences between scores prior to (2019) and during the pandemic (2021) were assessed. Linear regression was used to assess whether the 5-year trends (2017-2021) in outcome measures in relation to structure and process scores were statistically significant. Compound annual growth rates (CAGR) for each outcome were calculated to illustrate changes in outcome rates over time.

resultsAll public trusts in the Region (20) and a small number of private institutions (3) provided data for this study. A modest, non-significant improvement was found for 2021 structure, process, and total scores compared to respective 2019 scores. A significant improvement was found concerning the definition of a formal mission statement, whereas significantly less trusts included monitoring adherence to antimicrobial policy or treatment guidelines in their programs. Overall consumption of antibiotics for systemic use saw an increase in 2021, with 2021 recording the highest median overall consumption compared to all previous years considered in this study. Methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant enterobacteria (CRE) rates decreased over the 5-year period. Significant downwards trends in MRSA rates were identified for high-outlier structure and process groups.

conclusionsResults of this study suggest AMS programs in Piedmont were not set back following the pandemic. This outcome was possible thanks to well-established programs, coordinated within a regional framework. Continued efforts should be dedicated to supporting AMS programs and contrasting AMR, even when the focus is shifted towards other public health emergencies.

Indexed as

Antimicrobial StewardshipCOVID-19Anti-Bacterial AgentsCross InfectionHumansItalyPandemicsRetrospective StudiesSARS-CoV-2Anti-Bacterial AgentsAntimicrobial resistanceAntimicrobial stewardshipAntimicrobial usageCOVID-19ItalyPandemicQuality improvementQuality indicators

Identifiers

PMID38725026
PMCPMC11084085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.