Evidence map›Paper›PMID 38724885›Full record

ArticlePhysiological reports2024

Expression and localization of the mechanosensitive/osmosensitive ion channel TMEM63B in the mouse urinary tract.

Marianela G Dalghi, Ella DuRie, Wily G Ruiz, Dennis R Clayton, Nicolas Montalbetti, Stephanie B Mutchler, Lisa M Satlin, Thomas R Kleyman, Marcelo D Carattino, Yun Stone Shi and 1 more

Abstract read
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marianela G DalghiDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ella DuRieDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Wily G RuizDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Dennis R ClaytonDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nicolas MontalbettiDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Stephanie B MutchlerDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lisa M SatlinDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Thomas R KleymanDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2413-5415
Marcelo D CarattinoDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yun Stone ShiMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China.
Gerard ApodacaDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2432-4435

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
Role of AJC in umbrella cell function and dysfunctionR01DK129473 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2025
$3.2M
Role of PIEZO Channels in Bladder Function and DysfunctionR01DK119183 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, CARATTINO, MARCELO DANIEL · 2019 to 2023
$3.0M
Role of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3M
Role of fibroblasts in bladder mucosal functionR01DK138907 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerard L Apodaca, Marcelo Daniel Carattino · 2025 to 2026
$1.4M
Role of acid-sensing ion channels in bladder sensory signalingR01DK134431 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2023 to 2025
$941k
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R01 DK119183NIDDK NIH HHS R01 DK129285NIDDK NIH HHS R01 DK129473NIDDK NIH HHS R01 DK134431NIDDK NIH HHS R01 DK138907NIDDK NIH HHS T32 DK007052NIDDK NIH HHS U54 DK137329NIH HHS S10 OD028596
6 · The paper itself

Abstract

The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to these stimuli remain obscure. Candidates include the OSCA/TMEM63 family of ion channels, which can function as mechanosensors and osmosensors. Using Tmem63b

Indexed as

Calcium ChannelsUrinary TractAnimalsEpithelial CellsFemaleMaleMechanotransduction, CellularMiceMice, Inbred C57BLUrotheliumCalcium ChannelsbladderkidneymechanotransductionTMEM63Burethra

Identifiers

PMID38724885
PMCPMC11082094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.