Evidence map›Paper›PMID 38724756›Full record

ArticleCell biochemistry and biophysics2024

17β-estradiol Inhibits Oxidative Stress-Induced Apoptosis in Endometrial Cancer Cells by Promoting FOXM1 Expression.

Ge Xu, Jiao Wang, Xiaojie Mao, Maohong Xu

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ge XuThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. xug1232023@163.com.
Jiao WangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. wangja20@lzu.edu.cn.
Xiaojie MaoThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. maoxj20@lzu.edu.cn.
Maohong XuThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The steroid hormone 17β-estradiol (E2) has a significant impact on the development and progression of tumors. E2 stimulates tumor cell growth and metabolism, leading to an increase in reactive oxygen species (ROS) production. However, the rise in ROS levels is not sufficient to cause severe harm to cancer cells. and the mechanisms that regulate ROS are not well understood. Since FOXM1 plays a crucial role in the production of ROS, we aimed to investigate the impact of E2 on oxidative stress and the involvement of FOXM1 in the Ishikawa endometrial cancer cell line. Our research revealed that E2 controls the levels of ROS inside cells and safeguards them from apoptosis by promoting the expression of FOXM1. We observed a decrease in the expression of FOXM1 alongside an increase in oxidative damage. Moreover, cells demonstrated elevated levels of FOXM1 and ERα upon E2 treatment. Overall, our findings suggest that E2 prevents apoptosis induced by oxidative stress in endometrial cancer cells by encouraging the expression of FOXM1, potentially affecting ERα.

Indexed as

ApoptosisEndometrial NeoplasmsEstradiolEstrogen Receptor alphaForkhead Box Protein M1Oxidative StressReactive Oxygen SpeciesCell Line, TumorFemaleHumansEstradiolEstrogen Receptor alphaForkhead Box Protein M1FOXM1 protein, humanReactive Oxygen SpeciesApoptosisEndometrial cancerEstrogenEstrogen receptorOxidative stress

Identifiers

PMID38724756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.