ArticleNature communications2024
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.Respiratory research · 2026Pooled it
- Characterizing the Epithelial Transcriptome of Type-2 High Chronic Rhinosinusitis.International forum of allergy & rhinology · 2026Article
- Effectiveness of mepolizumab on mucus plugs and clinical outcomes in severe eosinophilic asthma with and without coexisting bronchiectasis: a prospective pilot study.ERJ open research · 2026Article
- Chemogenetic placental activation and proteomic extracellular vesicle signatures predict functional roles across pregnancy and postpartum.American journal of physiology. Endocrinology and metabolism · 2026Article
- Airway epithelial transcriptional response to daily high-dose inhaled corticosteroids in asthma.ERJ open research · 2026Article
- Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production.Respiratory research · 2026Article
- Mucus Plugging as a Treatable Trait Across the Asthma-COPD Spectrum: The Role of Type 2 Cytokine Blockade and Quantitative Imaging.Biomedicines · 2026Review
- Machine learning integrated extracellular vesicle proteome analysis for early markers of bronchopulmonary dysplasia.Function (Oxford, England) · 2026Article
- Intelectin-2 is a broad-spectrum antimicrobial lectin.Nature communications · 2026Article
- Deacetylation of SOD3 by sirtuins restores furin cleavage.Redox biochemistry and chemistry · 2025Article
- The immunology of asthma.Nature immunology · 2025Review
- Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.Particle and fibre toxicology · 2025Article
- Causal Correlations Between Plasma Metabolites, Inflammatory Proteins, and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization and Bioinformatics-Based Investigation.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
57 authors.
Jamie L EvermanCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.ORCID http://orcid.org/0000-0002-1935-4672
Satria P SajuthiCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.ORCID http://orcid.org/0000-0001-9598-7298
Maude A LiegeoisDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7015-5970
Nathan D JacksonCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Erik H ColletDepartment of Cell and Developmental Biology, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0009-0007-0307-5226
Michael C PetersDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Maurizio ChioccioliDepartment of Genetics and Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Camille M MooreCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Bhavika B PatelCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Nathan DyjackCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Roger PowellDepartment of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Cydney RiosCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Michael T MontgomeryCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.ORCID http://orcid.org/0000-0002-6748-2329
Celeste EngDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Jennifer R ElhawaryDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3326-1680
Angel C Y MakDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5372-4198
Donglei HuDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0351-001X
Scott HuntsmanDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Sandra SalazarDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Luigi FerianiBiological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6349-7833
Ana Fairbanks-MahnkeCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Gianna L ZinnenCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Cole R MichelDepartment of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Joe GomezDepartment of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Xing ZhangDepartment of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Vivian MedinaCentro de Neumología Pediatrica, San Juan, PR, USA.
Hong Wei ChuDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Pietro CicutaBiological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9193-8496
Erin D GordonDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Pamela ZeitlinDepartment of Pediatrics, National Jewish Health, Denver, CO, USA.
Victor E OrtegaMayo Clinic, Phoenix, AZ, USA.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Eleanor M DunicanSchool of Medicine, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-4014-5100
Monica TangDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8847-5817
Brett M ElickerUniversity of California-San Francisco, San Francisco, CA, USA.
Travis S HenryDuke University, Durham, NC, USA.
Eugene R BleeckerDepartment of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.
Mario CastroUniversity of Kansas Medical Center, Kansas City, KS, USA.ORCID http://orcid.org/0000-0001-6328-8994
Serpil C ErzurumCleveland Clinic, Cleveland, OH, USA.
Elliot IsraelHarvard University, Cambridge, MA, USA.
Bruce D LevyBrigham and Women's Hospital and Harvard University, Cambridge, MA, USA.
David T MaugerPennsylvania State University, Hershey, PA, USA.
Deborah A MeyersDepartment of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.
Kaharu SuminoDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
David S GieradaWashington University, St. Louis, MO, USA.
Annette T HastieWake Forest University School of Medicine, Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston Salem, NC, USA.ORCID http://orcid.org/0000-0001-6607-7797
Wendy C MooreWake Forest University School of Medicine, Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston Salem, NC, USA.
Loren C DenlingerUniversity of Wisconsin-Madison, Madison, WI, USA.
Nizar N JarjourUniversity of Wisconsin-Madison, Madison, WI, USA.
Mark L SchieblerUniversity of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-9120-5428
Sally E WenzelUniversity of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4242-0164
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Jose Rodriguez-SantanaCentro de Neumología Pediatrica, San Juan, PR, USA.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-1915-6593
Esteban G BurchardDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
John V FahyDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Max A SeiboldCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA. seiboldm@njhealth.org.ORCID http://orcid.org/0000-0002-8685-4263
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle · 2008 to 2026
$41.1MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2012 to 2023
$23.3MRapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MProtein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2MTranscriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0MTranscriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1MClinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0MGenes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8MCentriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5MGenetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1MFusion Lumos Orbitrap System for Quantitative Proteomics and Metabolomics ApplicationsS10OD028538 · OD · UNIVERSITY OF COLORADO DENVER · PI REISDORPH, NICHOLE A · 2021 to 2021
$1.3MNHLBI NIH HHS K24 HL137013NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL080414NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109146NIAID NIH HHS U19 AI077439NIGMS NIH HHS R35 GM140813NIH HHS S10 OD028538NIMHD NIH HHS R01 MD010443
Abstract
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC
Indexed as
AsthmaGPI-Linked ProteinsInterleukin-13LectinsMucin 5ACMucusChildCytokinesEpithelial CellsHumansNasal MucosaPolymorphism, GeneticRespiratory MucosaCytokinesGPI-Linked ProteinsIL13 protein, humanInterleukin-13ITLN1 protein, humanLectinsMUC5AC protein, humanMucin 5AC
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