Evidence map›Paper›PMID 38724006›Full record

ArticleJournal of advanced research2024

Sodium citrate targeting Ca

Yulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Article
  7. PRRC2A-mediated mCell death & disease · 2026
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  8. Quercetin ameliorates aflatoxin BJournal of animal science and biotechnology · 2026
    Article
  9. Article
  10. Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yulun WuNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China.
Chaoran JiaNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Wei LiuNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Wei ZhanThe Hospital of Northeast Normal University, Changchun 130024, China.
Yao ChenNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Junlin LuNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Yongli BaoNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China.
Shuyue WangNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Chunlei YuNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Lihua ZhengNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China.
Luguo SunNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China. Electronic address: [email protected].
Zhenbo SongNMPA Key Laboratory for Quality Control of Cell and Gene Therapy Medicine Products, Northeast Normal University, Changchun 130024, China. Electronic address: [email protected].

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOvarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.

objectivesTo analyze the inhibitory effect of sodium citrate on ovarian cancer cells and the underlying mechanism.

methodsCell apoptosis was examined by TUNEL staining, flow cytometry, and ferroptosis was examined intracellular Fe

resultsThis study suggested that sodium citrate not only promoted ovarian cancer cell apoptosis but also triggeredferroptosis, manifested as elevated levels of Fe

conclusionThese results revealed that the sodium citrate exerted its anti-cancer activity by inhibiting Ca

Indexed as

ApoptosisCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseFerroptosisOvarian NeoplasmsSodium CitrateAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationFemaleHumansMiceReactive Oxygen SpeciesSignal TransductionXenograft Model Antitumor AssaysAntineoplastic AgentsCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanReactive Oxygen SpeciesSodium CitrateApoptosisCa(2+)CAMKK2FerroptosisSodium citrate

Identifiers

PMID38724006
PMCPMC11518946

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.