Evidence map›Paper›PMID 38723172›Full record

ArticleProtein science : a publication of the Protein Society2024

Addition of sodium malonate alters the morphology and increases the critical flux during tangential flow filtration of precipitated immunoglobulins.

Ali Behboudi, Mirko Minervini, Zachary S Badinger, William W Haddad, Andrew L Zydney

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In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ali BehboudiDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Mirko MinerviniDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Zachary S BadingerDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
William W HaddadDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Andrew L ZydneyDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-1865-9156

Funding

U.S. Food and Drug Administration 75F40121C00111
6 · The paper itself

Abstract

Recent studies have demonstrated that one can control the packing density, and in turn the filterability, of protein precipitates by changing the pH and buffer composition of the precipitating solution to increase the structure/order within the precipitate. The objective of this study was to examine the effect of sodium malonate, which is known to enhance protein crystallizability, on the morphology of immunoglobulin precipitates formed using a combination of ZnCl

Indexed as

MalonatesCalorimetry, Differential ScanningChemical PrecipitationChloridesFiltrationImmunoglobulinsMalatesPolyethylene GlycolsZinc CompoundsChloridesImmunoglobulinsMalatesMalonatesmalonic acidPolyethylene Glycolszinc chlorideZinc Compoundsimmunoglobulinsmonoclonal antibodyprecipitationsodium malonatetangential flow filtration

Identifiers

PMID38723172
PMCPMC11081521

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.