ReviewChemical reviews2024
Regioselective Substitution of BINOL.
Review in Chemical reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Transforming Molecular Synthesis With Large Language Models.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Aqueous NaRSC advances · 2026Article
- Practical synthesis and photophysical characterization of full-color circularly polarized luminescent 4,7-diaryl-5,6-(RSC advances · 2026Article
- Rational design of a fluorescent probe for the enantioselective and chemoselective recognition of chiral cysteine in wheat.Food chemistry: X · 2026Article
- Chiral separation of typical binaphthyl atropisomers using binary systems of natural deep eutectic solvents and β-cyclodextrin derivatives by miniaturized capillary electrophoresis with amperometric detection.Mikrochimica acta · 2026Article
- Delicate molecular design, self-assembly and functional applications of chiral cyclophanes.Chemical science · 2026Review
- Rapid enantioselective fluorescence recognition and chiral separation of free amino acids.Nature communications · 2026Article
- Binol as a Bioisosteres for Hairpin and Parallel β-pleated Sheet Mimetic Foldamer.Chemistry, an Asian journal · 2026Article
- Atroposelective synthesis of sterically hindered stereochemically complex BINOL derivativesChemical science · 2025Article
- Synthesis and Chiroptical Properties of Bithiophene-Functionalized Open and Methylene-Bridged Binaphthyl Derivatives.The Journal of organic chemistry · 2025Article
- Article
- Enantiomer-enriched π-extended helicenes with a perylene core from binaphthol: axial-to-helical chirality transfer with a stepwise Scholl reaction mechanism.Chemical science · 2025Article
- Synthesis and resolution of a 1,1'-biazulene analogue of BINOL.RSC advances · 2025Article
- A stereodynamic probe of Pt(II) molecular hinge for chiroptical sensing of cryptochiral compounds.Nature communications · 2025Article
- Tailored chiral phosphoramidites support highly enantioselective Pd catalysts for asymmetric aminoalkylative amination.Nature communications · 2024Article
- Synthesis, non-spherical structure refinement and Hirshfeld surface analysis of racemic 2,2'-diisobut-oxy-1,1'-bi-naphthalene.Acta crystallographica. Section E, Crystallographic communications · 2024Article
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Authors and funding
1 author.
Funding
Abstract
1,1'-Bi-2-naphthol (BINOL) has been extensively used as the chirality source in the fields of molecular recognition, asymmetric synthesis, and materials science. The direct electrophilic substitution at the aromatic rings of the optically active BINOL has been developed as one of the most convenient strategies to structurally modify BINOL for diverse applications. High regioselectivity has been achieved for the reaction of BINOL with electrophiles. Depending upon the reaction conditions and substitution patterns, various functional groups can be introduced to the specific positions, such as the 6-, 5-, 4-, and 3-positions, of BINOL. Ortho-lithiation at the 3-position directed by the functional groups at the 2-position of BINOL have been extensively used to prepare the 3- and 3,3'-substituted BINOLs. The use of transition metal-catalyzed C-H activation has also been explored to functionalize BINOL at the 3-, 4-, 5-, 6-, and 7-positions. These regioselective substitutions of BINOL have allowed the construction of tremendous amount of BINOL derivatives with fascinating structures and properties as reviewed in this article. Examples for the applications of the optically active BINOLs with varying substitutions in asymmetric catalysis, molecular recognition, chiral sensing and materials are also provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.