Protective Effects of Polysaccharide of Atractylodes Macrocephala Koidz against Porcine Aortic Valve Endothelial Cells Damage Induced by di (2-ethylhexyl) Phthalate.

Yunfeng Liu, Zongyi Sun, Xiaoling Zhou, Haibin Wang, Miaomiao Yu, Dejun Li

Abstract read

In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunfeng Liu *College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

Zongyi Sun *College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.

Xiaoling ZhouCentre for Animal Disease Prevention and Control of Heilongjiang Province, Haerbin, 150069, China.

Haibin WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

Miaomiao YuJournal Center of Northeast Agricultural University, Northeast Agricultural University, Harbin, 150030, China.

Dejun LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. lidejun@neau.edu.cn.

Funding

Natural Science Fundation of Heilongjiang province project C201136Scientific and Technological cooperation projects 86000300

6 · The paper itself

Abstract

The activation, injury, and dysfunction of endothelial cells are considered to be the initial key events in the development of atherosclerosis. Di (2-ethylhexyl) phthalate (DEHP), a prevalent organic pollutant, can cause damage to multiple organs. Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a bioactive compound extracted from A. macrocephala Koidz with various biological activities. This study investigates the protective effects of PAMK on porcine aortic valve endothelial cells (PAVEC) damaged by DEHP. PAVECs treated with DEHP alone or with PAMK showed reduced cell apoptosis and death in PAMK-pretreated cells. PAMK up-regulated Bcl-2 expression and down-regulated Bax protein, suppressing apoptosis. Flow cytometry analysis demonstrated that PAMK protected PAVECs from DEHP-induced damage. These findings suggest that PAMK inhibits cell apoptosis and protects against DEHP damage in endothelial cells.

Indexed as

Aortic ValveApoptosisAtractylodesbcl-2-Associated X ProteinDiethylhexyl PhthalateEndothelial CellsProto-Oncogene Proteins c-bcl-2AnimalsCells, CulturedPolysaccharidesProtective AgentsSwinebcl-2-Associated X ProteinDiethylhexyl PhthalatePolysaccharidesProtective AgentsProto-Oncogene Proteins c-bcl-2ApoptosisDi (2-ethylhexyl) phthalatePAVECsPolysaccharide of Atractylodes Macrocephala Koidz

Identifiers

PMID38722472

DOI10.1016/j.ceb.2003.10.009

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.