Evidence map›Paper›PMID 38722417›Full record

ArticleJournal of mammary gland biology and neoplasia2024

In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth.

Laura J A Hardwick, Benjamin P Davies, Sara Pensa, Maedee Burge-Rogers, Claire Davies, André Figueiredo Baptista, Robert Knott, Ian S McCrone, Eleonora Po, Benjamin W Strugnell and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mammary gland biology and neoplasia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Methods and Models in Mammary Gland Biology and Breast Cancer Research.Journal of mammary gland biology and neoplasia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laura J A Hardwick *Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Benjamin P Davies *Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Sara PensaDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Maedee Burge-RogersDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Claire DaviesThe Fold Farm Vets Ltd, Tyne Green, Hexham, Northumberland, UK.
André Figueiredo BaptistaDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Robert KnottDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Ian S McCroneDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Eleonora PoDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.ORCID 0000-0002-9777-6707
Benjamin W StrugnellFarm Post Mortems Ltd, Durham, UK.ORCID 0000-0001-9808-8626
Katie WaineFarm Post Mortems Ltd, Durham, UK.
Paul WoodDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Walid T KhaledDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Huw D SummersDepartment of Biomedical Engineering, Swansea University, Swansea, UK.
Paul ReesDepartment of Biomedical Engineering, Swansea University, Swansea, UK.
John W WillsDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. jw2020@cam.ac.uk.ORCID 0000-0002-4347-5394
Katherine HughesDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. kh387@cam.ac.uk.ORCID 0000-0002-3331-1249

Funding

Anatomical Society PhD StudentshipBritish Veterinary Association Animal Welfare Foundation Norman Hayward Fund NHF_2016_03_KHPeterhouse Research Fellowship
6 · The paper itself

Abstract

Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments.

Indexed as

Epithelial CellsMammary Glands, AnimalSTAT3 Transcription FactorAnimalsCattleFemaleMiceParturitionPhosphorylationPregnancySignal TransductionStat3 protein, mouseSTAT3 Transcription FactorMacrophageMammaryParturitionSpatial statisticsSTAT3Udder

Identifiers

PMID38722417
PMCPMC11081984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.