Evidence map›Paper›PMID 38722385›Full record

ArticleEuropean journal of nutrition2024

Iron absorption in adults with sickle cell anemia: a stable-isotope approach.

Juliana Omena, Flávia Fioruci Bezerra, Vanessa Monteiro Voll, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Carmen Marino Donangelo, Gustavo Federico Jauregui, Andrea Soares Ribeiro, Cláudia Dos Santos Cople Rodrigues, Marta Citelli

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Juliana OmenaNutrition Institute, Rio de Janeiro State University, São Francisco Xavier Street, 524, 12144F, Maracanã, Rio de Janeiro, 20550-900, Brazil. omenaju@gmail.com.ORCID https://orcid.org/0000-0003-4639-1898
Flávia Fioruci Bezerra *Nutrition Institute, Rio de Janeiro State University, São Francisco Xavier Street, 524, 12144F, Maracanã, Rio de Janeiro, 20550-900, Brazil.ORCID https://orcid.org/0000-0002-6594-4323
Vanessa Monteiro Voll *Nutrition Institute, Rio de Janeiro State University, São Francisco Xavier Street, 524, 12144F, Maracanã, Rio de Janeiro, 20550-900, Brazil.ORCID https://orcid.org/0000-0002-0939-0071
Bernardo Ferreira BrazInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ricardo Erthal SantelliInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-9812-6098
Carmen Marino DonangeloSchool of Nutrition, University of the Republic, Montevideo, Uruguay.ORCID https://orcid.org/0000-0002-4243-4179
Gustavo Federico JaureguiRadiology Department, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.
Andrea Soares RibeiroHematology Department, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.
Cláudia Dos Santos Cople RodriguesNutrition Institute, Rio de Janeiro State University, São Francisco Xavier Street, 524, 12144F, Maracanã, Rio de Janeiro, 20550-900, Brazil.ORCID https://orcid.org/0000-0001-9497-556X
Marta CitelliNutrition Institute, Rio de Janeiro State University, São Francisco Xavier Street, 524, 12144F, Maracanã, Rio de Janeiro, 20550-900, Brazil. martacitelli@gmail.com.ORCID https://orcid.org/0000-0003-1380-3729

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408401/2017-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26-010.100930/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.963/2022Ministry of Health 777022/2012
6 · The paper itself

Abstract

purposeIron absorption in sickle cell anemia (SCA) remains unclear and studies in adults with SCA are scarce. The aim of this study was to evaluate the iron absorption SCA adults and its association with iron status and hepcidin concentration.

methodsSCA patients (n = 13; SCA

resultsIron absorption in the control group ranged from 0.3 to 26.5% (median = 0.9%), while it varied from 0.3 to 5.4% in SCAio+ (median = 0.5%) and from 0.3 to 64.2% in the SCAio- (median = 6.9%). Hepcidin median values were 14.1 ng/mL (3.0-31.9 ng/mL) in SCAio-, 6.2 ng/mL (3.3-7.8 ng/mL) in SCAio + and 6.2 ng/mL (0.6-9.3 ng/mL) in control. Iron absorption was associated with ferritin level (r = - 0.641; p = 0.018) and liver iron concentration (LIC; r = - 0.786; p = 0.036) in the SCA

conclusionOur data suggest that SCAio- individuals may be at risk of developing primary IO. Simultaneously, secondary IO may induce physiological adaptation, resulting in reduced iron absorption. Further studies evaluating intestinal iron absorption using larger sample sizes should be conducted to help establish a safe nutrition approach to be adopted and to ensure the security of food-fortifying public policies for these patients.

trial registrationThis trial was registered at www.ensaiosclinicos.gov.br (Identifier RBR-4b7v8pt).

Indexed as

Anemia, Sickle CellHepcidinsIntestinal AbsorptionIron IsotopesAdultFemaleFerritinsHumansIronIron, DietaryIron OverloadMaleMiddle AgedNutritional StatusYoung AdultFerritinsHepcidinsIronIron, DietaryIron IsotopesBioavailabilityFerritinHepcidinIron overloadLiver iron concentration

Identifiers

PMID38722385

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None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.