Evidence map›Paper›PMID 38722139›Full record

ReviewFuture oncology (London, England)2024

Unraveling noncoding DNA variants and epimutations: a paradigm shift in hereditary cancer research.

Maria Baz Ibrahim, James Flanagan, Tony Ibrahim, Etienne Rouleau

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria Baz IbrahimDepartment of Oncogenetics & Tumor Biology, Paul Brousse Hospital, Villejuif, France.
James FlanaganDepartment of Surgery & Cancer, Ovarian Cancer Action Research Centre, Imperial College London, London, W12 8EE, UK.
Tony IbrahimInternational Department of Medical Oncology, Gustave Roussy, 94805, Villejuif, France.ORCID 0000-0001-9728-8554
Etienne RouleauDepartment of Biology & Pathology-Cancer Genetics Laboratory, Gustave Roussy, 94805, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exhaustive efforts have been dedicated to uncovering genomic aberrations linked to cancer susceptibility. Noncoding sequence variants and epigenetic alterations significantly influence gene regulation and could contribute to cancer development. However, exploring noncoding regions in hereditary cancer susceptibility demands cutting-edge methodologies for functionally characterizing genomic discoveries. Additionally, comprehending the impact on cancer development of variants in noncoding DNA and the epigenome necessitates integrating diverse data through bioinformatic analyses. As novel technologies and analytical methods continue to advance, this realm of research is rapidly gaining traction. Within this mini-review, we delve into future research domains concerning aberrations in noncoding DNA regions, such as pseudoexons, promoter variants and

Indexed as

Epigenesis, GeneticGenetic Predisposition to DiseaseMutationNeoplasmsComputational BiologyDNA, IntergenicGenetic VariationGenomicsHumansPromoter Regions, GeneticDNA, IntergenicDNA methylationepimutationhereditary cancernoncoding DNApromoter variantspseudoexons

Identifiers

PMID38722139
PMCPMC11318707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.