Evidence map›Paper›PMID 38722049›Full record

ArticleACS biomaterials science & engineering2024

PEGylated Recombinant

Alena M Wolkersdorfer, Birgit Bergmann, Juliane Adelmann, Matthias Ebbinghaus, Eckhard Günther, Marcus Gutmann, Lukas Hahn, Robert Hurwitz, Ralf Krähmer, Frank Leenders and 6 more

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alena M WolkersdorferInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0001-5449-8789
Birgit BergmannChair of Microbiology, Biocentre, University of Würzburg, 97074 Würzburg, Germany.
Juliane AdelmannInstitute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Matthias EbbinghausCharles River Laboratories Germany GmbH, Am Flughafen 12-14, 79108 Freiburg, Germany.
Eckhard GüntherAeterna Zentaris GmbH, Weismuellerstr. 50, 60314 Frankfurt am Main, Germany.
Marcus GutmannInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0001-6000-7923
Lukas HahnInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Robert HurwitzMax-Planck-Institute for Infection Biology, Virchowweg 12, 10117 Berlin, Germany.
Ralf KrähmerCelares GmbH, Otto-Warburg-Haus, 13125 Berlin, Germany.
Frank LeendersCelares GmbH, Otto-Warburg-Haus, 13125 Berlin, Germany.
Tessa LühmannInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0001-7552-6435
Julia SchuelerCharles River Laboratories Germany GmbH, Am Flughafen 12-14, 79108 Freiburg, Germany.
Luisa SchmidtInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Michael TeifelAeterna Zentaris GmbH, Weismuellerstr. 50, 60314 Frankfurt am Main, Germany.
Lorenz MeinelInstitute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0002-7549-7627
Thomas RudelChair of Microbiology, Biocentre, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0003-4740-6991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a novel treatment method for cancer has emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by arginine deaminases like the l-amino acid oxidase found in the ink toxin of the sea hare

Indexed as

AplysiaArginineLysinePolyethylene GlycolsAnimalsCell Line, TumorFemaleHumansL-Amino Acid OxidaseMarine ToxinsMiceRecombinant ProteinsXenograft Model Antitumor AssaysArginineL-Amino Acid OxidaseLysineMarine ToxinsPolyethylene GlycolsRecombinant Proteinsarginine-auxotrophyarginine lysine starvationl-amino acid oxidasepatient-derived tumorPEGylationtumor therapy

Identifiers

PMID38722049
PMCPMC11168412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.