Evidence map›Paper›PMID 38722021›Full record

ArticleeLife2024

SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize

Pascal Forcella, Niklas Ifflander, Chiara Rolando, Elli-Anna Balta, Aikaterini Lampada, Claudio Giachino, Tanzila Mukhtar, Thomas Bock, Verdon Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pascal Forcella *Department of Biomedicine, University of Basel, Basel, Switzerland.
Niklas Ifflander *Department of Biomedicine, University of Basel, Basel, Switzerland.
Chiara Rolando *Department of Biomedicine, University of Basel, Basel, Switzerland.
Elli-Anna BaltaDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Aikaterini LampadaDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Claudio GiachinoDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Tanzila MukhtarDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Thomas BockProteomics Core Facility, Biozentrum, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-9314-5318
Verdon TaylorDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3497-5976

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_162609Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_182388
6 · The paper itself

Abstract

Neural stem cells (NSCs) are multipotent and correct fate determination is crucial to guarantee brain formation and homeostasis. How NSCs are instructed to generate neuronal or glial progeny is not well understood. Here, we addressed how murine adult hippocampal NSC fate is regulated and described how scaffold attachment factor B (SAFB) blocks oligodendrocyte production to enable neuron generation. We found that SAFB prevents NSC expression of the transcription factor nuclear factor I/B (NFIB) by binding to sequences in the

Indexed as

HippocampusNeural Stem CellsNFI Transcription FactorsNuclear Matrix-Associated ProteinsRNA, MessengerAnimalsCell DifferentiationDNA-Binding ProteinsMiceOligodendrogliaRibonuclease IIIRNA-Binding ProteinsRNA StabilityDNA-Binding ProteinsDrosha protein, mouseNfib protein, mouseNFI Transcription FactorsNuclear Matrix-Associated ProteinsRibonuclease IIIRNA-Binding ProteinsRNA, Messengerscaffold attachment factor B1, mouseadult neurogenesisDroshamouseneural stem cellsneurosciencepost-transcriptional gene regulationregenerative medicineSAFBstem cells

Identifiers

PMID38722021
PMCPMC11149935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.