Evidence map›Paper›PMID 38721896›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Associations and Mediating Pathways Between Childhood Adversity and Risk of Dementia: A Cohort Study in the UK Biobank.

Wei Hu, Wei-Bo Zhang, Bao-Peng Liu, Cun-Xian Jia

Abstract read
PubMed Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Adverse Childhood Experiences and Later-Life Cognitive Aging: Persistent Methodological Challenges Limit the Evidence Base.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Wei HuDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Wei-Bo ZhangDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Bao-Peng LiuDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID 0000-0003-1277-7397
Cun-Xian JiaDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

Natural Science Foundation of Shandong Province ZR2021QH310
6 · The paper itself

Abstract

backgroundWhile childhood adversity (CA) is known to be associated with multiple adverse outcomes, its link with dementia is an area with limited exploration and inconsistent agreement. The study aimed to examine the longitudinal associations of CA with incident all-cause dementia and to quantify the potential mediating pathways.

methodsData from the UK Biobank. CA, encompassing neglect and abuse, was evaluated retrospectively by an online mental health questionnaire. Physical performance, psychological factors, lifestyles, and biological indicators assessed at baseline were considered potential mediators. Incident all-cause dementia was defined by International Classification of Diseases, Tenth Revision codes obtained through self-reported medical conditions, primary care, hospital admission, and death registrations. Cox proportional hazard models were applied to estimate the longitudinal associations. Mediation analyses were conducted on potential mediators to examine their contribution.

resultsThis cohort study comprised 150 152 nondemented individuals (mean [SD] age, 55.9 [7.7] years) at baseline (2006-2010). Compared to individuals who did not experience CA, those exposed to any CA exhibited a 30.0% higher risk of dementia (hazard ratio = 1.300, 95% confidence interval [CI]: 1.129-1.496). Each additional CA was associated with a 15.5% (95% CI: 8.8%-22.5%, pfor trend < .001) increased dementia risks. Depression, smoking, and low grip strength explained 8.7%, 2.4%, and 0.9% of the associations, respectively. Biomarkers involving inflammation, erythrocytes, liver, and kidney function mediated the associations by 0.6%-1.4%.

conclusionsThe study revealed the detrimental effects of CA on dementia and identified some potential mediators, namely depression, smoking, low grip strength, and several targeted biomarkers. In addition to calling more attention to CA, the findings underscore the importance of interventions targeting modifiable mediators in preventing dementia.

Indexed as

Adverse Childhood ExperiencesBiological Specimen BanksDementiaAgedCohort StudiesFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesRisk FactorsUK BiobankUnited KingdomChildhood adversityCohort studyIncident dementiaMediators

Identifiers

PMID38721896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.