ArticleClinical and experimental immunology1985
Hypergammaglobulinaemia in Leishmania donovani infected hamsters: possible association with a polyclonal activator of B cells and with suppression of T cell function.
Article in Clinical and experimental immunology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Experimental models in vaccine research: malaria and leishmaniasis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Review
- Article
- A Leishmania infantum cytosolic tryparedoxin activates B cells to secrete interleukin-10 and specific immunoglobulin.Immunology · 2008Article
- Article
- A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Host Cell Phenotypic Variability Induced by Trypanosomatid-Parasite-Released Immunomodulatory Factors: Physiopathological Implications.Journal of biomedicine & biotechnology · 2004Article
- Dual role of the Leishmania major ribosomal protein S3a homologue in regulation of T- and B-cell activation.Infection and immunity · 2001Article
- Transforming growth factor beta and immunosuppression in experimental visceral leishmaniasis.Infection and immunity · 1998Article
- Immune complex glomerulonephritis in experimental kala-azar. II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters.Clinical and experimental immunology · 1992Article
- Cyclophosphamide affects the dynamics of granuloma formation in experimental visceral leishmaniasis.Parasitology research · 1992Article
- Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters.Infection and immunity · 1989Article
- Antibodies to tubulin in patients with parasitic infections.Clinical and experimental immunology · 1987Article
- Immunogenicity in dogs and protection against visceral leishmaniasis induced by a 14kDaTrials in vaccinologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Studies were carried out on the mechanisms by which B lymphocytes are polyclonally activated to secrete antibodies during visceral leishmaniasis. Crude extracts of Leishmania donovani, the aetiological agent of this disease, of Leishmania mexicana amazonensis, the etiological agent of cutaneous leishmaniasis, and of Herpetomonas muscarum, a related non-pathogenic organism, all contain components which cause strong in vitro polyclonal activation of hamster spleen cells leading to the production of antibodies. However, in vivo, only hamsters infected with L. donovani develop hypergammaglobulinaemia due to B cell polyclonal activation. Hamsters injected with the crude extracts of leishmania or infected with L. mexicana amazonensis do not manifest these alterations in their B cell response. Furthermore spleen cells of hamsters infected with L. donovani became unresponsive to stimulation with the T cell mitogen phytohaemagglutinin (PHA) by day 10 of infection, whereas their response to concanavalin A (Con A) was preserved. The decreased lymphocyte response to PHA coincided with the augmentation of the PFC/spleen ratio. In contrast, spleen cells from hamsters infected with L. mexicana amazonensis, responded normally to both mitogens throughout the course of infection. These results suggest that the hypergammaglobulinaemia present in visceral leishmaniasis may be the consequence of an inbalance of regulatory T cells, possibly associated with a direct stimulation of hamster B cells by L. donovani components.
Indexed as
Identifiers
3872189PMC1577132W2210542What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.