Evidence map›Paper›PMID 38721616›Full record

ArticleFrontiers in psychiatry2024

The effects of BDNF rs6265 and FGF21 rs11665896 polymorphisms on alcohol use disorder-related impulsivity in Han Chinese adults.

Shizhuo Yang, Fan Wang, Lanrong Sun, Xinqian Liu, Siyuan Li, Yingjie Chen, Lingling Chen, Zeheng Pan, Yimin Kang, Yu-Hsin Chen and 5 more

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Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Shizhuo YangDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, China.
Fan WangBeijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Lanrong SunSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Xinqian LiuDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, China.
Siyuan LiSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yingjie ChenCixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, China.
Lingling ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Zeheng PanSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yimin KangPsychosomatic Medicine Research Division, Inner Mongolia Medical University, Hohhot, China.
Yu-Hsin ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Wei WangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Li ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Xiaokun LiSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.
Chonghui TangDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, China.
Yanlong LiuZhejiang Provincial Clinical Research Center for Mental Disorders, the Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients with alcohol use disorder (AUD) often experience repeated withdrawal. Impulsivity is the most relevant factor influencing successful withdrawal. Brain-derived neurotrophic factor (BNDF) and fibroblast growth factor 21 (FGF21) are associated with impulsivity. Previous studies on the differential effects of BDNF or FGF21 on impulsivity have focused on single-gene effects and have inconsistent results. We aim to investigate the effects of BDNF rs6265 and FGF21 rs11665896, individually and together, on impulsivity during alcohol withdrawal in patients with AUD. Methods: We recruited 482 adult Han Chinese males with AUD and assessed their impulsivity using the Barratt Impulsivity Scale. Genomic DNA was extracted and genotyped from peripheral blood samples. Statistical analysis was conducted on the data. Results: The T-test and 2 × 2 analysis of variance were used to investigate the effects of the genes on impulsivity. There was a significant BDNF × FGF21 interaction on no-planning impulsiveness ( Conclusion and significance: The combination of BDNF rs6265 A allele and FGF21 rs11665896 T allele may increase impulsivity and discourage alcohol withdrawal. Our study provides a possible genetic explanation for the effects of associated impulsivity in patients with AUD from the perspective of gene-gene interactions.

Indexed as

alcohol use disorderalcohol withdrawalBDNFFGF21impulsivity

Identifiers

PMID38721616
PMCPMC11078301

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