A transaminase-mediated aldol reaction and applications in cascades to styryl pyridines.

Yu Wang, Yiwen Li, Yeke Ni, Dejan-Krešimir Bučar, Paul A Dalby, John M Ward, Jack W E Jeffries, Helen C Hailes

Abstract read

In one paragraph

Article in Catalysis science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu WangDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.ORCID https://orcid.org/0000-0002-7611-7710

Yiwen LiDepartment of Biochemical Engineering, University College London Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.

Yeke NiDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.

Dejan-Krešimir BučarDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.ORCID https://orcid.org/0000-0001-6393-276X

Paul A DalbyDepartment of Biochemical Engineering, University College London Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0002-0980-8167

John M WardDepartment of Biochemical Engineering, University College London Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0002-4415-5544

Jack W E JeffriesDepartment of Biochemical Engineering, University College London Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0003-4143-2339

Helen C HailesDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.ORCID https://orcid.org/0000-0001-5574-4742

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025

$5.2M

NIGMS NIH HHS R01 GM129325

6 · The paper itself

Abstract

Transaminase enzymes are well established biocatalysts that are used in chemical synthesis due to their beneficial sustainability profile, regio- and stereoselectivity and substrate specificity. Here, the use of a wild-type

Identifiers

PMID38721397

DOI10.1039/d3cy01370g

PMCPMC11075132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.