Evidence map›Paper›PMID 38721302›Full record

ArticleActa biochimica Polonica2024

Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis.

Joanna I Loch, Anna Ściuk, Marta Kilichowska, Izabela Pieróg, Weronika Łukaszczyk, Katarzyna Zimowska, Mariusz Jaskolski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica Polonica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Towards a dependable data set of structures for L-asparaginase research.Acta crystallographica. Section D, Structural biology · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna I LochDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Anna ŚciukDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Marta KilichowskaDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Izabela PierógDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Weronika ŁukaszczykDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Katarzyna ZimowskaDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
Mariusz JaskolskiInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report describes a comprehensive approach to local random mutagenesis of the

Indexed as

AmidohydrolasesEscherichia coliMutagenesisAmino Acid SequenceEscherichia coli ProteinsModels, MolecularMutationAmidohydrolasesEscherichia coli ProteinsAlphaFold predictionenzyme engineeringL-asparaginaseNtn-hydrolaserandom mutagenesis

Identifiers

PMID38721302
PMCPMC11077353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.