Evidence map›Paper›PMID 38721191›Full record

ArticleCureus2024

Formulation of a Novel Polymeric Hydrogel Membrane for Periodontal Tissue Regeneration Using Tricalcium Phosphate-Alginate Reinforcement.

Swetha G, Priyangha P T, Anju Cecil, Chithra S, Nidhita Suresh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Biomaterial Scaffolds for Periodontal Tissue Engineering.Journal of functional biomaterials · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Swetha GDepartment of Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Priyangha P TDepartment of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Anju CecilDepartment of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Chithra SDepartment of Biomaterials, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Nidhita SureshDepartment of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe primary goal of periodontal therapy is to facilitate the regeneration of tissues damaged by periodontal disease. In recent years, there has been a growing utilization of guided tissue regeneration (GTR) membranes with bioabsorbable properties as these membranes are increasingly employed to guide the growth of gingival tissue away from the root surface. Both resorbable and non-resorbable membranes currently employed act as physical barriers, preventing the ingrowth of connective and epithelial tissues into the defect and thereby facilitating periodontal tissue regeneration.

objectiveThis study aimed to develop a polymeric hydrogel membrane reinforced with tricalcium phosphate (TCP)-alginate and assess its potential for periodontal regeneration. MATERIALS AND

methodsTCP nanoparticles were incorporated into the alginate mixture to form TCP alginate. Subsequently, the mixture was cross-linked with calcium chloride to produce a TCP-alginate polymeric hydrogel membrane. The membrane underwent hemocompatibility analysis, and also scanning electron microscopy and Fourier-transform infrared (FTIR) spectroscopy analyses were done.

resultsThe SEM analysis revealed granulations and a bonded thread-like structure in the membrane, indicative of favorable conditions for cell attachment necessary for periodontal regeneration. FTIR analysis showed characteristic peaks in the spectrum, including those attributed to phosphate ion (PO4-3) at 1000.85 cm-1 and 600 cm-1, indicating the presence of β-TCP phases. Hemocompatibility assessment demonstrated a hemolysis rate of less than 5% for the TCP-alginate membrane, which is found to be within the limits.

conclusionThe developed TCP-reinforced alginate membrane exhibited hemocompatibility and safety, suggesting its suitability for utilization in periodontal therapy as an effective regenerative material.

Indexed as

alginatehemocompatibilityhydrogelpolymeric membranetricalcium phosphate

Identifiers

PMID38721191
PMCPMC11078324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.