Evidence map›Paper›PMID 38720925›Full record

ArticleADMET & DMPK2024

Antimalarial evaluation of alkyl-linked bis-thiadiazine derivatives in murine model infected with two

Katherine Loachamin-Gualotuña, Lilian M Spencer, Hortensia Rodriguez, Abigail Montero-Calderon, Beatriz Pernia, Julieta Coro, Margarita Suarez, Francisco Javier Tingo-Jácome, Zully J Rodriguez-Parra, José Manuel Lozano and 1 more

Abstract read
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In one paragraph

Article in ADMET & DMPK, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katherine Loachamin-GualotuñaSchool of Biological Sciences and Engineering, University of Investigation and Experimental Technology Yachay, 100650, Ecuador.
Lilian M SpencerSchool of Biological Sciences and Engineering, University of Investigation and Experimental Technology Yachay, 100650, Ecuador.
Hortensia RodriguezSchool of Chemical Sciences and Engineering, University of Investigation and Experimental Technology Yachay, 100650, Ecuador.
Abigail Montero-CalderonSchool of Agricultural and Agro-industrial Sciences, University of Investigation and Experimental Technology Yachay, 100650, Ecuador.
Beatriz PerniaUniversity of Guayaquil, Faculty of Natural Sciences, Guayaquil, Ecuador.
Julieta CoroLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400, Cuba.
Margarita SuarezLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400, Cuba.
Francisco Javier Tingo-JácomeBiology Center, Central University of Ecuador, Ecuador.
Zully J Rodriguez-ParraUniversidad Nacional de Colombia, Departamento de Farmacia, Mimetismo Molecular de los Agentes Infecciosos, Colombia.
José Manuel LozanoUniversidad Nacional de Colombia, Departamento de Farmacia, Mimetismo Molecular de los Agentes Infecciosos, Colombia.
Jesús A Cortés-VecinoUniversidad Nacional de Colombia, Departamento de Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Experimental Approach: This study aimed to perform an Key Results: For each compound, we assess the percentages of parasitemia by smears from tail blood and the humoral response by indirect ELISA test using each compound as an antigen. We also evaluated the B lymphocyte response and the cytotoxicity of the bis-THTT derivatives compounds with MTT cell proliferation assays. Conclusions: Our results show that the bis-THTT derivatives JH2 and JH4 presented effective parasitemia control in mice infected with

Indexed as

Bis-thiadiazinesdrugshumoral responseparasitemiaPlasmodium bergheiPlasmodium yoelii

Identifiers

PMID38720925
PMCPMC11075161

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.