Evidence map›Paper›PMID 38720332›Full record

SynthesisCritical care (London, England)2024

Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis.

Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio and 12 more

Abstract readSystematic ReviewNetwork Meta-Analysis
In one paragraph

Synthesis in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Tommaso Pettenuzzo *Institute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy.
Annalisa Boscolo *Institute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy.
Elisa PistollatoDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Chiara PrettoDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Tommaso Antonio GiaconDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Sara FrassonDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Francesco Maria CarbottiDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Francesca MediciDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Giovanni PettenonDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Giuliana CarofiglioDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Marco NardelliDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Nicolas CucciDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Clara Letizia TuccioDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Veronica GagliardiDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Chiara SchiavolinDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Caterina SimoniDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Sabrina CongediDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Francesco MonteleoneDepartment of Medicine, University of Padua, 2 Via Giustiniani, 35128, Padua, Italy.
Francesco ZarantonelloInstitute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy.
Nicolò SellaInstitute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy.
Alessandro De CassaiInstitute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy.
Paolo NavalesiInstitute of Anesthesia and Intensive Care, University Hospital of Padua, 13 Via Gallucci, 35121, Padua, Italy. paolo.navalesi@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRe-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery.

methodsA systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed.

resultsThirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, I

conclusionsIn post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure.

Indexed as

Noninvasive VentilationHumansIntensive Care UnitsLength of StayPostoperative PeriodRespiratory InsufficiencyContinuous positive airway pressureConventional oxygen therapyExtubationGeneral anesthesiaHigh-flow nasal oxygenNon-invasive ventilationPost-operative respiratory failure

Identifiers

PMID38720332
PMCPMC11077852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.