Evidence map›Paper›PMID 38720250›Full record

Trial reportBMC anesthesiology2024

Effects of perioperative low-dose naloxone on the immune system in patients undergoing laparoscopic-assisted total gastrectomy: a randomized controlled trial.

Xiangzhen Min, Yan Ma, Yufang Leng, Xiaoxi Li, Jianmin Zhang, Shoucai Xu, Xiuqin Wang, Renjun Lv, Jie Guo, Huaixin Xing

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangzhen MinThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
Yan MaDepartment of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinanm, Shandong Province, China.
Yufang LengDepartment of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China. lengyf@lzu.edu.cn.
Xiaoxi LiThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
Jianmin ZhangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
Shoucai XuDepartment of Anesthesiology, Shandong Cancer Hospital and Institute Affiliated to Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China.
Xiuqin WangDepartment of Anesthesiology, Shandong Cancer Hospital and Institute Affiliated to Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China.
Renjun LvThe First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
Jie GuoDepartment of Anesthesiology, Shandong Cancer Hospital and Institute Affiliated to Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China.
Huaixin XingDepartment of Anesthesiology, Shandong Cancer Hospital and Institute Affiliated to Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China. xinghuaixin521@163.com.

Funding

Beijing Medical Award Foundation No YXJL-2023-0551-0143.
6 · The paper itself

Abstract

backgroundLow immune function after laparoscopic total gastrectomy puts patients at risk of infection-related complications. Low-dose naloxone (LDN) can improve the prognosis of patients suffering from chronic inflammatory diseases or autoimmune diseases. The use of LDN during perioperative procedures may reduce perioperative complications. The purpose of this study was to examine the effects of LDN on endogenous immune function in gastric cancer patients and its specific mechanisms through a randomized controlled trial.

methodsFifty-five patients who underwent laparoscopic-assisted total gastrectomy were randomly assigned to either a naloxone group (n = 23) or a nonnaloxone group (n = 22). Patients in the naloxone group received 0.05 µg/kg-1.h

resultsCompared with the nonnaloxone group, the naloxone group exhibited a lower incidence of infection (in the incision, abdomen, and lungs) (P < 0.05). The numbers of NK cells and CD8

conclusionLaparoscopic total gastrectomy patients can benefit from 0.05 ug/kg

trial registrationThe trial was registered at the Chinese Clinical Trial Registry on 24/11/2023 (ChiCTR2300077948).

Indexed as

GastrectomyLaparoscopyNaloxonePostoperative ComplicationsStomach NeoplasmsAgedFemaleHumansInterleukin-6MaleMiddle AgedNarcotic AntagonistsPerioperative CareToll-Like Receptor 4Interleukin-6NaloxoneNarcotic AntagonistsToll-Like Receptor 4Immune functionLaparoscopic-assisted total gastrectomyLow-dose naloxonePostoperative complications

Identifiers

PMID38720250
PMCPMC11077871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.