Evidence map›Paper›PMID 38720082›Full record

ArticleNature2024

Label-free detection and profiling of individual solution-phase molecules.

Lisa-Maria Needham, Carlos Saavedra, Julia K Rasch, Daniel Sole-Barber, Beau S Schweitzer, Alex J Fairhall, Cecilia H Vollbrecht, Sushu Wan, Yulia Elsner, Anders J Bergsten and 9 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Sub-parts-per-billion CONature communications · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Life beyond labels.Nature methods · 2025
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Lisa-Maria NeedhamDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Carlos SaavedraDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3165-9521
Julia K RaschDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0004-6556-6272
Daniel Sole-BarberDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Beau S SchweitzerDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-6872-2147
Alex J FairhallDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0007-5657-7027
Cecilia H VollbrechtDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0568-1242
Sushu WanDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Yulia ElsnerDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Anders J BergstenDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0009-3084-2376
Brandon MehlenbacherDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Zhao ZhangHoward Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-1133-4191
Lukas TenbrakeInstitut für Angewandte Physik, Universität Bonn, Bonn, Germany.
Jovanna SaimiDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Lucy C KneelyDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0006-2000-6014
Jackson S KirkwoodDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Hannes PfeiferInstitut für Angewandte Physik, Universität Bonn, Bonn, Germany.
Edwin R ChapmanHoward Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-9787-8140
Randall H GoldsmithDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA. rhg@chem.wisc.edu.ORCID http://orcid.org/0000-0001-9083-8592

Funding

Synaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7M
Structure and dynamics of exocytotic fusion poresR35NS097362 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPMAN, EDWIN R · 2017 to 2024
$4.6M
Development of Cavity-Enhanced Single-Molecule Electronic and Vibrational Spectroscopy for Mechanistic Studies of BiomoleculesR01GM136981 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, RANDALL H · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM136981NIMH NIH HHS R01 MH061876NINDS NIH HHS R35 NS097362
6 · The paper itself

Abstract

Most chemistry and biology occurs in solution, in which conformational dynamics and complexation underlie behaviour and function. Single-molecule techniques

Indexed as

PeptidesSingle Molecule ImagingDiffusionIsomerismLightMolecular WeightMotionProtein ConformationSignal-To-Noise RatioSolutionsPeptidesSolutions

Identifiers

PMID38720082
PMCPMC11694320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.