ArticleNature2024
Genome organization around nuclear speckles drives mRNA splicing efficiency.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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114citing papers in PubMed
–field-weighted citation impact
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Who cites it
114 citing papers in PubMed.
- Exchange dynamics and kinetic control of gene regulation complexes.Nature reviews. Molecular cell biology · 2026Review
- Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- RAC1 signaling in polyploid giant cancer cells: Implications for tumorigenesis and therapy resistance.Cancer letters · 2026Review
- Nuclear speckle protein SON safeguards efficient splicing of GC-rich genes.Cell research · 2026Article
- Phase Separation of SF3B1 Serves as a Critical Post-Transcriptional Regulator During Early Mouse Embryogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Acidic transcription factors position the genome at nuclear speckles through transcription-dependent and -independent mechanisms.Molecular cell · 2026Article
- The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis.Nature cell biology · 2026Article
- Proteostasis of organelles in aging and disease.The FEBS journal · 2026Review
- Nuclear speckles: a fundamental layer of gene regulation.Trends in cell biology · 2026Review
- Article
- Disruption of microhomology-mediated end joining in Ewing sarcoma.Molecular cell · 2026Article
- A mutation in the nuclear speckle and splicing factor SRRM2 is associated with multisystem proteinopathy and causes dysregulation of synapse-associated genes.RNA (New York, N.Y.) · 2026Article
- Nuclear speckle-associated perispeckle networks partition active chromatin into gene expression niches.Cell reports · 2026Article
- Genome folding and nuclear speckles converge to orchestrate fibroblast activation.Science advances · 2026Article
- Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program.Nature aging · 2026Article
- Active RNA synthesis patterns nuclear condensates.Cell systems · 2026Article
- Hierarchical Nuclear Architecture in Pre-mRNA Splicing: From IDRs to Speckles and Meshworks.International journal of molecular sciences · 2026Review
- mMolecular medicine reports · 2026Review
- Predicting human mRNA isoform levels from site-specific splicing kineticsbioRxiv : the preprint server for biology · 2026Article
- IL-6-driven POU2AF1 and ELL2 are key regulators of multiple myeloma-distinct transcriptional and splicing programs.Blood advances · 2026Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
18 authors.
Prashant BhatDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-3832-4871
Amy ChowDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Benjamin EmertDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Olivia EttlinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-9243-9752
Sofia A QuinodozDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Mackenzie StrehleDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-1410-8701
Yodai TakeiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-7226-5185
Alex BurrDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-2741-9592
Isabel N GoronzyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Allen W ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-6351-2578
Wesley HuangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-6483-8297
Jose Lorenzo M FerrerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-3405-7596
Elizabeth SoehalimDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Say-Tar GohDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tara ChariDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-6953-4313
Delaney K SullivanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Mario R BlancoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Mitchell GuttmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. mguttman@caltech.edu.ORCID http://orcid.org/0000-0003-4748-9352
Funding
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9MPREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9MDynamics of chromosome organization and chromatin states in single cellsU01DK127420 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAI, LONG, ELOWITZ, MICHAEL B · 2020 to 2024
$5.7MHow phase-separation in the nucleus organizes 3D spatial assembly and gene regulationR01DA053178 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GUTTMAN, MITCHELL · 2020 to 2024
$5.4MDetermining the function and mechanism of the MALAT1 long non-coding RNA in co-transcriptional splicingF30CA247447 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BHAT, PRASHANT · 2020 to 2021
$102kNCI NIH HHS F30 CA247447NIDA NIH HHS R01 DA053178NIDDK NIH HHS U01 DK127420NIGMS NIH HHS T32 GM007616NIGMS NIH HHS T32 GM008042
Abstract
The nucleus is highly organized, such that factors involved in the transcription and processing of distinct classes of RNA are confined within specific nuclear bodies
Indexed as
GenomeNuclear SpecklesRNA, MessengerRNA PrecursorsRNA SplicingSpliceosomesAnimalsGenesHuman Embryonic Stem CellsHumansMaleMiceMouse Embryonic Stem CellsTranscription, GeneticRNA, MessengerRNA Precursors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.