ArticleNature2024
The intrinsic substrate specificity of the human tyrosine kinome.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98citing papers in PubMed
–field-weighted citation impact
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Who cites it
98 citing papers in PubMed.
- A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity.Nature structural & molecular biology · 2026Article
- KSTAR v1.2: A faster and more and accessible KSTAR for kinase activity inference.bioRxiv : the preprint server for biology · 2026Article
- The multifaceted significance of phosphoinositides in endocytic trafficking.FEBS letters · 2026Review
- TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation.Genes & development · 2026Article
- Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases.ACS chemical biology · 2026Article
- Proteomic investigation of signaling dynamics: from static maps to network rewiring.Bioscience reports · 2026Review
- Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT.Nature communications · 2026Article
- ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB.The Journal of biological chemistry · 2026Article
- An AI-enabled structural atlas decodes kinase specificity across the human proteome.Nature biotechnology · 2026Article
- Phosphoproteomics Data-Driven Integrative Analysis of Autophosphorylation Sites in the Human Kinome.International journal of molecular sciences · 2026Article
- AXL phosphosite mapping links FAK1 and YAP1 signaling to erlotinib resistance in EGFR-mutant lung cancer.Cell reports · 2026Article
- Article
- Detecting protein higher-order structural changes using kinase as a phospho-labeler.Cell reports methods · 2026Article
- Synthetic Substrate Discovery for Hck Kinase via Phage Display.Biochemistry · 2026Article
- (Phospho)proteomic Profiling Reveals Mutation-Specific Adaptive Signaling to PI3Kα Inhibition inJournal of proteome research · 2026Article
- Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling.bioRxiv : the preprint server for biology · 2026Article
- Paracrine signals from HIV-1-infected immune cells reprogram cervical cancer pathways.iScience · 2026Article
- Phosphoproteome-derived peptide libraries for deep specificity profiling of phosphatases and phospholyases.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Context-dependent peptide recognition shapes tyrosine kinase substrate specificity beyond consensus motifs.bioRxiv : the preprint server for biology · 2026Article
- Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.Cellular & molecular biology letters · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Tomer M Yaron-BarirMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6574-7314
Brian A JoughinDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1022-9450
Emily M HuntsmanMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Alexander KerelskyMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Daniel M CizinMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Benjamin M CohenMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Amit RegevMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Junho SongMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Neil VasanDepartment of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-1779-484X
Ting-Yu LinMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jose M OrozcoDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Christina SchoenherrCancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0983-6168
Cari SagumDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mark T BedfordDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8899-1050
R Max WynnDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1879-2136
Shih-Chia TsoDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
David T ChuangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lei LiSchool of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China.
Shawn S-C LiDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada.ORCID 0000-0003-3610-9035
Pau CreixellDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Konstantin KrismerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-8994-3416
Mina TakegamiDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-3744-1577
Harin LeeDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
Bin ZhangDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
Jingyi LuDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
Ian CossentinoDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.ORCID 0000-0002-1179-2045
Sean D LandryDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
Mohamed UdumanDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
John BlenisMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3622-2337
Olivier ElementoEnglander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8061-9617
Margaret C FrameCancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5882-1942
Peter V HornbeckDepartment Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA.
Lewis C CantleyMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Lewis_Cantley@dfci.harvard.edu.ORCID 0000-0002-1298-7653
Benjamin E TurkDepartment of Pharmacology, Yale School of Medicine, New Haven, CT, USA. ben.turk@yale.edu.ORCID 0000-0001-9275-4069
Michael B YaffeDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.ORCID 0000-0002-9547-3251
Jared L JohnsonMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. jaredl_johnson@dfci.harvard.edu.ORCID 0000-0003-1802-6527
Funding
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU · 2006 to 2025
$41.7MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MRole of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2MProtein Kinase Signaling in the Genotoxic Stress ResponseR35ES028374 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 2017 to 2024
$3.9MRNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer TherapiesR01CA226898 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B, HEMANN, MICHAEL · 2019 to 2023
$2.7MModeling human phosphorylation networks through kinome-wide profilingR01GM104047 · NIGMS · YALE UNIVERSITY · PI TURK, BENJAMIN E, YAFFE, MICHAEL B · 2013 to 2017
$2.4MMechanisms of selective signaling in MAP kinase phosphorylation networksR01GM135331 · NIGMS · YALE UNIVERSITY · PI TURK, BENJAMIN E · 2020 to 2023
$1.4MNCI NIH HHS P01 CA117969NCI NIH HHS P01 CA120964NCI NIH HHS R01 CA226898NCI NIH HHS R35 CA197588NIEHS NIH HHS R35 ES028374NIGMS NIH HHS R01 GM104047NIGMS NIH HHS R01 GM135331
Abstract
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth
Indexed as
PhosphotyrosineProtein-Tyrosine KinasesSubstrate SpecificityTyrosineAmino Acid MotifsAnimalsEvolution, MolecularHumansMass SpectrometryPhosphoproteinsPhosphorylationProteomeProteomicsSignal Transductionsrc Homology DomainsPhosphoproteinsPhosphotyrosineProtein-Tyrosine KinasesProteomeTyrosine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.