ArticleNature2024
Complete biosynthesis of QS-21 in engineered yeast.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plantSynthetic and systems biotechnology · 2026Article
- Advances in large DNA fragment assembly for microbial cell factory engineering.Quantitative biology (Beijing, China) · 2026Review
- Nitrene generation and transfer for unnatural biosynthesis in living cells.Nature chemistry · 2026Article
- Cinchona alkaloid scaffold decoded.Plant communications · 2026Article
- A yeast-based platform for etoposide production via yatein bioconversion.Metabolic engineering communications · 2026Article
- Advances in the heterologous biosynthesis of QS saponins: a review.Microbial cell factories · 2026Review
- How Cinchona builds quinine.Nature chemical biology · 2026Article
- MechFind: a computational framework for de novo prediction of enzyme mechanisms.Nature communications · 2026Article
- Toward sustainable food preservatives: high-level production of sorbic acid in engineered Saccharomyces cerevisiae.Nature communications · 2026Article
- Multi-omics and functional analyses in Aesculus wilsonii elucidate the biosynthetic pathways of moretane- and oleanane-type triterpenoids.Plant communications · 2026Article
- Article
- Biomanufacturing of Natural Bioactive Compounds.Molecules (Basel, Switzerland) · 2026Article
- Telomere-to-telomere genome assembly and multiomics analyses illustrate the high accumulation of quercetin glucosides in tetraploidHorticulture research · 2026Article
- The Cinderella tree,Plants, people, planet · 2026Article
- Biodegradable Polymers for Application as Robust Immunomodulatory Biomaterial Carrier Systems.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Advances in artificial biosynthesis of bioactive plant natural products.Current opinion in biotechnology · 2026Review
- Advances in Adjuvanted Rabies Vaccines.Vaccines · 2026Review
- Engineering Saccharomyces cerevisiae to improve heterologous abscisic acid production.Microbial cell factories · 2026Article
- Improved de novo production of prostaglandin FCommunications biology · 2026Article
- Polyphyllin II Triggers Pyroptosis in Hepatocellular Carcinoma via Modulation of the ROS/NLRP3/Caspase-1/GSDMD Axis.Antioxidants (Basel, Switzerland) · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Yuzhong LiuCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-5614-1951
Xixi ZhaoCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
Fei GanCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-1670-5251
Xiaoyue ChenJoint BioEnergy Institute, Emeryville, CA, USA.
Kai DengJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0003-2937-8931
Samantha A CroweCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
Graham A HudsonCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
Michael S BelcherJoint BioEnergy Institute, Emeryville, CA, USA.
Matthias SchmidtJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0002-3363-4777
Maria C T AstolfiJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0001-6995-2497
Suzanne M KosinaEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0003-2885-1248
Bo PangCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
Minglong ShaoJoint BioEnergy Institute, Emeryville, CA, USA.
Jing YinJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0002-0029-5393
Sasilada SirirungruangJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0002-2624-5124
Anthony T IavaroneCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
James ReedJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0001-5780-6134
Laetitia B B MartinJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0002-6921-7246
Amr El-DemerdashJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0001-6459-2955
Shingo KikuchiJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0001-9033-6242
Rajesh Chandra MisraJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0001-9594-3789
Xiaomeng LiangJoint BioEnergy Institute, Emeryville, CA, USA.
Michael J CronceJoint BioEnergy Institute, Emeryville, CA, USA.
Xiulai ChenJoint BioEnergy Institute, Emeryville, CA, USA.
Chunjun ZhanJoint BioEnergy Institute, Emeryville, CA, USA.
Ramu KakumanuJoint BioEnergy Institute, Emeryville, CA, USA.
Edward E K BaidooJoint BioEnergy Institute, Emeryville, CA, USA.
Yan ChenJoint BioEnergy Institute, Emeryville, CA, USA.
Christopher J PetzoldJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0002-8270-5228
Trent R NorthenJoint BioEnergy Institute, Emeryville, CA, USA.ORCID 0000-0001-8404-3259
Anne OsbournJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID 0000-0003-2195-5810
Henrik SchellerJoint BioEnergy Institute, Emeryville, CA, USA.
Jay D KeaslingCalifornia Institute of Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA. keasling@berkeley.edu.ORCID 0000-0003-4170-6088
Funding
Synthetic biology tools for scalable production of medicinal plant terpenesR01AT010593 · NCCIH · STANFORD UNIVERSITY · PI KEASLING, JAY D, LANGE, BERND MARKUS · 2019 to 2023
$3.5MHigh Definition Ion Mobility SpectrometerS10OD020062 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILLIAMS, EVAN R · 2015 to 2015
$590kNCCIH NIH HHS R01 AT010593NIH HHS S10 OD020062
Abstract
QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans
Indexed as
Adjuvants, ImmunologicMetabolic EngineeringSaccharomyces cerevisiaeSaponinsBiosynthetic PathwaysDrug DesignEnzymesPlantsStructure-Activity RelationshipAdjuvants, ImmunologicEnzymessaponin QA-21V1Saponins
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.