Evidence map›Paper›PMID 38720025›Full record

Trial reportScientific reports2024

Prediction and mediation analysis for treatment responses to combined cognitive and physical training for older adults.

I-Ching Chuang, I-Chen Chen, Yih-Ru Wu, Kuan-Yi Li

2 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03619577 naunknown statusnot on this map

The Effectiveness of Combining Physical Exercise and Cognitive Training for Individuals With Mild Cognitive Impairment

TypeinterventionalSponsorChang Gung Memorial HospitalRan2018 to 2022Enrolled200ConditionsMild Cognitive ImpairmentArmsSequential training
NCT04689776 naunknown statusnot on this map

The Effectiveness of Dual Task Training in Elderly With Cognitive Decline

TypeinterventionalSponsorChang Gung Memorial HospitalRan2020 to 2023Enrolled80ConditionsMild Cognitive ImpairmentArmsDual-Task Training
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I-Ching ChuangDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, No. 259, Wunhua 1st Rd., Gueishan Township, Taoyuan, 333, Taiwan.
I-Chen ChenDepartment of Occupational Therapy, College of Nursing and Health Sciences, Da-Yeh University, Changhua, Taiwan.
Yih-Ru WuDepartment of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Kuan-Yi LiDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, No. 259, Wunhua 1st Rd., Gueishan Township, Taoyuan, 333, Taiwan. kyli@mail.cgu.edu.tw.

Funding

Chang Gung Memorial Hospital BMRPC58Chang Gung Memorial Hospital BMRPJ29Healthy Aging Research Center at Chang Gung University EMRPD1M0411Ministry of Science and Technology, Taiwan MOST 109-2314-B-182-008-MY2
6 · The paper itself

Abstract

Diminished cognitive and physical functions negatively affect the daily functions of individuals. Although combined cognitive and physical training prevents instrumental activities of daily living (IADL) disability in older adults, no predictive model or mediation analysis of IADL after combined training exists. This study aims to employ prediction and mediation analysis to identify the predictors of IADL performance and to elucidate the mediators of the association between baseline global cognition and subsequent IADL performance following combined cognitive and physical training. This study involved 177 participants aged 60 years and older who underwent combined training. Cognitive function was measured with the Montreal Cognitive Assessment (MoCA), Digit Symbol Substitution Test (DSST), Color Trails Test, Word List, and a dual task; physical function with the Timed Up and Go (TUG) test; daily function with the Lawton IADL Scale. We conducted regression analyses to identify the predictors of IADL performance, and mediation analysis to examine whether DSST and TUG mediate the relationship between MoCA and IADL. The pre-intervention DSST and TUG were significant independent predictors of post-intervention IADL. The association between the pre-intervention MoCA and post-intervention IADL was mediated by pre-intervention DSST and TUG. This study highlighted the importance of measuring and improving processing speed and functional mobility before and during interventions to enhance IADL outcomes.Trial registration: NCT03619577, 23/07/2018; NCT04689776, 29/12/2020.

Indexed as

Activities of Daily LivingCognitionAgedAged, 80 and overExercise TherapyFemaleHumansMaleMediation AnalysisMiddle AgedTreatment OutcomeCombined cognitive and physical trainingFunctional mobilityInstrumental activities of daily livingMediatorPredictorProcessing speed

Identifiers

PMID38720025
PMCPMC11079002

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.