Evidence map›Paper›PMID 38719837›Full record

ArticleNature communications2024

Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs.

Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda LauingerDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA. llauinge@uci.edu.
Anna AndronicosDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Karin FlickDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Clinton YuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.
Geetha DurairajDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Lan HuangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0002-3140-4687
Peter KaiserDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA. pkaiser@uci.edu.ORCID http://orcid.org/0000-0002-3326-0090

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Supplement: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome SystemR35GM145249 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lan Huang · 2022 to 2026
$3.2M
Ubiquitin and Metabolite SignalingR35GM148350 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Peter Kaiser · 2023 to 2026
$2.7M
NCI NIH HHS P30 CA062203NCI NIH HHS T32 CA009054NIGMS NIH HHS R35 GM145249NIGMS NIH HHS R35 GM148350
6 · The paper itself

Abstract

The F-box domain is a highly conserved structural motif that defines the largest class of ubiquitin ligases, Skp1/Cullin1/F-box protein (SCF) complexes. The only known function of the F-box motif is to form the protein interaction surface with Skp1. Here we show that the F-box domain can function as an environmental sensor. We demonstrate that the F-box domain of Met30 is a cadmium sensor that blocks the activity of the SCF

Indexed as

CadmiumProtein BindingSKP Cullin F-Box Protein LigasesCell Cycle ProteinsF-Box ProteinsHumansProtein DomainsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS-Phase Kinase-Associated ProteinsStress, PhysiologicalUbiquitinationValosin Containing ProteinCadmiumCell Cycle ProteinsF-Box ProteinsSaccharomyces cerevisiae ProteinsSKP Cullin F-Box Protein LigasesS-Phase Kinase-Associated ProteinsValosin Containing Protein

Identifiers

PMID38719837
PMCPMC11079001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.