Evidence map›Paper›PMID 38719790›Full record

ReviewAlcohol, clinical & experimental research2024

The gut microbiome in alcohol use disorder and alcohol-associated liver disease: A systematic review of clinical studies.

Erica N Grodin, Elizabeth M Burnette, Crystal Rodriguez, Jennifer A Fulcher, Lara A Ray

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-5528-4918
Elizabeth M BurnetteBrain Research Institute, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-4005-5885
Crystal RodriguezDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Jennifer A FulcherDivision of Infectious Diseases, David Gefen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5734-9444

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
Microbiome and Mucosal Immune Interactions in the Pathogenesis of HIV-1 TransmissionK08AI124979 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FULCHER, JENNIFER · 2018 to 2021
$617k
Probing Inflammation and Reward Sensitivity in Alcohol Use DisorderF31AA028976 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURNETTE, ELIZABETH · 2020 to 2022
$103k
Doris Duke Charitable Foundation 2019086NIAAA NIH HHS F31 AA028976NIAAA NIH HHS K01 AA029712NIAAA NIH HHS K24 AA025704NIAID NIH HHS K08 AI124979NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

Evidence suggests that a relationship exists between the gut microbiome and the pathogenesis of alcohol use disorder (AUD) and alcohol-associated liver disease (AALD). This systematic review identified studies that investigated the gut microbiome in individuals with an AUD or an AALD. A search was conducted on October 27, 2022, in PubMed, Web of Science, and Embase databases. Fifty studies satisfied eligibility criteria. Most studies found evidence for gut dysbiosis in individuals with AUD and AALD. Microbiome intervention studies have mostly been conducted in AALD patients; fecal microbial transplant interventions show the most promise. Because most studies were conducted cross-sectionally, the causal relationship between the gut microbiome and alcohol use is unknown. Furthermore, almost all studies have been conducted in predominantly male populations, leaving critical questions regarding sex differences and generalizability of the findings. The study summaries and recommendations provided in this review seek to identify areas for further research and to highlight potential gut microbial interventions for treating AUD and AALD.

Indexed as

alcohol‐associated liver diseasealcohol use disordergut microbiome

Identifiers

PMID38719790
PMCPMC11827555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.