Evidence map›Paper›PMID 38719595›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Disseminated Histoplasmosis Presenting with Panniculitis and Macrophage Activation Syndrome in a Patient Undergoing Immunosuppressive Therapy for Mixed Connective Tissue Disease (MCTD).

Hirotoshi Kawashima, Aiko Saku, Mai Konishi, Yuichiro Hayashi, Akira Watanabe, Koichi Hirose

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. ColonicACG case reports journal · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hirotoshi KawashimaDepartment of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.
Aiko SakuDepartment of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.
Mai KonishiDepartment of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.
Yuichiro HayashiDepartment of Pathology, International University of Health and Welfare Narita Hospital, Japan.
Akira WatanabeMedical Mycology Research Center, Chiba University, Japan.
Koichi HiroseDepartment of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled with molecular confirmation led to final a diagnosis. This case emphasizes the diagnostic challenges associated with histoplasmosis in immunocompromised patients and underscores the importance of considering it in the differential diagnosis of any atypical presentation in rheumatic patients.

Indexed as

HistoplasmosisImmunosuppressive AgentsMacrophage Activation SyndromeMixed Connective Tissue DiseasePanniculitisDiagnosis, DifferentialFemaleHistoplasmaHumansImmunocompromised HostMiddle AgedImmunosuppressive Agentsfungal ITS sequencehistoplasmosisMCTD

Identifiers

PMID38719595
PMCPMC11781929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.