ArticleJournal of the American College of Cardiology2024
Magnetic Resonance Imaging Characterization and Clinical Outcomes of Dilated and Arrhythmogenic Left Ventricular Cardiomyopathies.
Article in Journal of the American College of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07351838 (Prognosis and Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognosis and Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy : Cardiac MRI Insights for Better Outcomes
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction of ventricular arrhythmias and sudden cardiac death by quantification and location of late gadolinium enhancement on cardiac magnetic resonance: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Pooled it
- Non-Dilated Left Ventricular Cardiomyopathy: Exploring the Spectrum from Phenotype to Disease Entity.Journal of clinical medicine · 2026Review
- Arrhythmogenic right ventricular cardiomyopathy with left ventricular noncompaction: A phenotypic overlap with high arrhythmic risk.HeartRhythm case reports · 2026Article
- Classification of cardiomyopathies: bringing order to complexity.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Non-Dilated Left Ventricular Cardiomyopathy (NDLVC): A Name, Multiple Souls.Current cardiology reports · 2026Review
- Prognostic Value of Multimodal Cardiac Magnetic Resonance Parameters in Patients with Nondilated Left Ventricular Cardiomyopathy and Reduced Left Ventricular Ejection Fraction.Journal of clinical medicine · 2026Article
- Temporal Variability of ECG Risk Markers and Clinical Outcomes in Non-Dilated Left Ventricular Cardiomyopathy.Journal of clinical medicine · 2026Article
- Multimodal Imaging Evaluation of Non-Dilated Left Ventricular Cardiomyopathy: The Importance of Cardiac Magnetic Resonance Imaging.International medical case reports journal · 2026Article
- Pathological classification of non-ischaemic dilated cardiomyopathy based on deep learning.European heart journal. Digital health · 2026Article
- What Should a Clinical Cardiologist Know About Cardiogenetics?Journal of the American Heart Association · 2025Review
- CMR-LGE imaging features of dilated cardiomyopathy and relationship with left ventricular function.Scientific reports · 2025Article
- Titin Cardiomyopathy, Emerging Evidence: More Than A Big Heart.Current cardiology reports · 2025Review
- Integrated role of cardiac magnetic resonance and genetics in predicting left ventricular reverse remodelling in dilated and non-dilated cardiomyopathy.European journal of heart failure · 2025Observational
- SCN5A Cardiomyopathy: from Ion Channel Dysfunction To Clinical Disease.Current cardiology reports · 2025Review
- Late gadolinium enhancement imaging and sudden cardiac death.European heart journal · 2025Review
- A prognostically meaningful definition of non-dilated left ventricular cardiomyopathy.The international journal of cardiovascular imaging · 2025Article
- Variant-Specific Late Gadolinium Enhancement Patterns Influence Clinical Outcomes inJournal of the American Heart Association · 2025Article
- Contemporary practice and resource availability for genetic testing in paediatric hypertrophic cardiomyopathy.Journal of medical genetics · 2025Article
- CarDiac magnEtic Resonance for prophylactic Implantable cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE registry.European heart journal. Cardiovascular Imaging · 2025Observational
- Article
Corrections and comments
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Authors and funding
31 authors.
Funding
Abstract
backgroundNondilated left ventricular cardiomyopathy (NDLVC) has been recently differentiated from dilated cardiomyopathy (DCM). A comprehensive characterization of these 2 entities using cardiac magnetic resonance (CMR) and genetic testing has never been performed.
objectivesThis study sought to provide a thorough characterization and assess clinical outcomes in a large multicenter cohort of patients with DCM and NDLVC.
methodsA total of 462 patients with DCM (227) or NDLVC (235) with CMR data from 4 different referral centers were retrospectively analyzed. The study endpoint was a composite of sudden cardiac death or major ventricular arrhythmias.
resultsIn comparison to DCM, NDLVC had a higher prevalence of pathogenic or likely pathogenic variants of arrhythmogenic genes (40% vs 23%; P < 0.001), higher left ventricular (LV) systolic function (LV ejection fraction: 51% ± 12% vs 36% ± 15%; P < 0.001) and higher prevalence of free-wall late gadolinium enhancement (LGE) (27% vs 14%; P < 0.001). Conversely, DCM showed higher prevalence of pathogenic or likely pathogenic variants of nonarrhythmogenic genes (23% vs 12%; P = 0.002) and septal LGE (45% vs 32%; P = 0.004). Over a median follow-up of 81 months (Q1-Q3: 40-132 months), the study outcome occurred in 98 (21%) patients. LGE with septal location (HR: 1.929; 95% CI: 1.033-3.601; P = 0.039) was independently associated with the risk of sudden cardiac death or major ventricular arrhythmias together with LV dilatation, older age, advanced NYHA functional class, frequent ventricular ectopic activity, and nonsustained ventricular tachycardia.
conclusionsIn a multicenter cohort of patients with DCM and NDLVC, septal LGE together with LV dilatation, age, advanced disease, and frequent and repetitive ventricular arrhythmias were powerful predictors of major arrhythmic events.
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