ArticleThe British journal of ophthalmology2024
Enhancing the structure-function relationship in glaucoma using anatomical compensation of retinal nerve fibre layer.
Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quadrant-specific anatomical architecture of the peripapillary retinal nerve fiber layer: a spectral-domain optical coherence tomography study.Surgical and radiologic anatomy : SRA · 2026Article
- The retinal nerve fibre layer thickness slope: a localised biomarker of the structure-function relationship in early glaucoma.The British journal of ophthalmology · 2026Article
- Electric Cataract After High-Voltage Craniofacial Injury With Preserved Optic Nerve Microvasculature: A Case Report.Clinical case reports · 2026Article
- Deep Learning Prediction of Personalized Peripapillary Retinal Nerve Fiber Layer Thickness Norms from Fundus Images in Glaucoma.medRxiv : the preprint server for health sciences · 2026Article
- Sectoral Analysis of Corneal Thickness in Glaucoma and Healthy Eyes and Its Relationship with RNFL and Rim Area.Journal of clinical medicine · 2026Article
- Visual field prediction using K-means clustering in patients with primary open angle glaucoma.International journal of ophthalmology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo investigate whether compensating retinal nerve fibre layer (RNFL) thickness measurements for demographic and anatomical ocular factors can strengthen the structure-function relationship in patients with glaucoma.
methods600 eyes from 412 patients with glaucoma (mean deviation of the visual field (MD VF) -6.53±5.55 dB) were included in this cross-sectional study. Participants underwent standard automated perimetry and spectral-domain optical coherence tomography imaging (Cirrus; Carl Zeiss Meditec). Compensated RNFL thickness was computed considering age, refractive error, optic disc parameters and retinal vessel density. The relationship between MD VF and RNFL thickness measurements, with or without demographic and anatomical compensation, was evaluated sectorally and focally.
resultsThe superior arcuate sector exhibited the highest correlation between measured RNFL and MD VF, with a correlation of 0.49 (95% CI 0.37 to 0.59). Applying the compensated RNFL data increased the correlation substantially to 0.62 (95% CI 0.52 to 0.70; p<0.001). Only 61% of the VF locations showed a significant relationship (Spearman's correlation of at least 0.30) between structural and functional aspects using measured RNFL data, and this increased to 78% with compensated RNFL measurements. In the 10°-20° VF region, the slope below the breakpoint for compensated RNFL thickness demonstrated a more robust correlation (slope=1.66±0.18 µm/dB; p<0.001) than measured RNFL (slope=0.27±0.67 µm/dB; p=0.688).
conclusionCompensated RNFL data improve the correlation between RNFL measurements and VF parameters. This indicates that creating structure-to-function maps that consider anatomical variances may aid in identifying localised structural and functional loss in glaucoma.
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