Evidence map›Paper›PMID 38719318›Full record

ArticleBMJ open2024

Comprehensive observational study evaluating the enduring effectiveness of 4CMenB, the meningococcal B vaccine against gonococcal infections in the Northern Territory and South Australia, Australia: study protocol.

Helen Marshall, James Ward, Bing Wang, Prabha Andraweera, Mark McMillan, Louise Flood, Charlotte Bell, Jana Sisnowski, Vicki Krause, Rosalind Webby and 12 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Helen MarshallVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia helen.marshall@adelaide.edu.au.ORCID 0000-0003-2521-5166
James WardPoche Centre, The University of Queensland, Brisbane, Queensland, Australia.
Bing WangVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Prabha AndraweeraVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Mark McMillanVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia.ORCID 0000-0002-6490-7707
Louise FloodCommunicable Disease Control Branch, Department for Health and Wellbeing, Government of South Australia, Adelaide, South Australia, Australia.
Charlotte BellCommunicable Disease Control Branch, Department for Health and Wellbeing, Government of South Australia, Adelaide, South Australia, Australia.
Jana SisnowskiCommunicable Disease Control Branch, Department for Health and Wellbeing, Government of South Australia, Adelaide, South Australia, Australia.
Vicki KrauseCentre for Disease Control & Environmental Health, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Rosalind WebbyCentre for Disease Control & Environmental Health, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Emma ChildsImmunisation and Notifiable Diseases, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Manoji GunathilakeCentre for Disease Control & Environmental Health, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Natasha EgoroffCentre for Disease Control & Environmental Health, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Lex LeongSA Pathology, SA Health, Government of South Australia, Adelaide, South Australia, Australia.
Andrew LawrenceSA Pathology, SA Health, Government of South Australia, Adelaide, South Australia, Australia.
Rob BairdTerritory Pathology, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Kevin FreemanTerritory Pathology, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
Dimitrios MenouhosTerritory Pathology, NT Health, Northern Territory Government, Darwin, Northern Territory, Australia.
David M WhileyUQ Centre for Clinical Research, The University of Queensland and Pathology Queensland, Brisbane, Queensland, Australia.
Jonathan KarnonCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Sebastian van HalMicrobiology, NSW Health Pathology, Sydney, New South Wales, Australia.
Monica M LahraMicrobiology, NSW Health Pathology, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe effectiveness of antibiotics for treating gonococcal infections is compromised due to escalating antibiotic resistance; and the development of an effective gonococcal vaccine has been challenging. Emerging evidence suggests that the licensed meningococcal B (MenB) vaccine, 4CMenB is effective against gonococcal infections due to cross-reacting antibodies and 95% genetic homology between the two bacteria, METHODS AND ANALYSES: This observational study will provide long-term evaluation results of the effectiveness of the 4CMenB vaccine against gonococcal infections at 4-7 years post 4CMenB programme implementation. Routine notifiable disease notifications will be the basis for assessing the impact of the vaccine on gonococcal infections. Pathology laboratories will provide data on the number and percentage of ETHICS AND DISSEMINATION: The protocol and all study documents have been reviewed and approved by the SA Department for Health and Well-being Human Research Ethics Committee (HREC/2022/HRE00308), and the evaluation will commence in the NT on receipt of approval from the NT Health and Menzies School of Health Research Human Research Ethics Committee. Results will be published in peer-reviewed journals and presented at scientific meetings and public forums.

Indexed as

GonorrheaMeningococcal VaccinesNeisseria gonorrhoeaeFemaleHumansNorthern TerritoryObservational Studies as TopicSouth Australia4CMenB vaccineMeningococcal VaccinesAdolescentPublic healthSexually Transmitted DiseaseVaccination

Identifiers

PMID38719318
PMCPMC11086485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.