Evidence map›Paper›PMID 38719306›Full record

SynthesisBMJ open2024

Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus.

Verónica Pingray, Caitlin R Williams, Fadhlun M Alwy Al-Beity, Edgardo Abalos, Sabaratnam Arulkumaran, Alejandro Blumenfeld, Brendan Carvalho, Catherine Deneux-Tharaux, Soo Downe, Alexandre Dumont and 27 more

Abstract readSystematic ReviewConsensus Statement
In one paragraph

Synthesis in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. FIGO recommendations on objective measurement of blood loss after birth for early detection of postpartum hemorrhage.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. FIGO call to action: Multisectoral approach to postpartum hemorrhage.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Verónica PingrayInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina vpingray@iecs.org.ar.ORCID 0000-0002-7889-2825
Caitlin R WilliamsInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.ORCID 0000-0002-4925-869X
Fadhlun M Alwy Al-BeityDepartment of Obstetrics & Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.
Edgardo AbalosMaternidad Martin, Secretaría de Salud Pública de la Municipalidad de Rosario, Rosario, Santa Fe, Argentina.
Sabaratnam ArulkumaranDepartment of Obstetrics & Gynaecology, St George's Hospital, London, UK.
Alejandro BlumenfeldInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Brendan CarvalhoStanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-4919-4542
Catherine Deneux-TharauxObstetrical Perinatal and Pediatric Epidemiology Research team, Centre for Research in Statistics and Epidemiology (CRESS) Université Paris Cité INSERM, Paris, France.
Soo DowneResearch in Childbirth and Health, University of Central Lancashire, Preston, UK.
Alexandre DumontCEPED, Université Paris Cité, IRD, INSERM, Paris, France.
Maria Fernanda EscobarDepartamento de Ginecología y Obstetricia, Fundación Valle del Lili, Cali, Colombia.
Cherrie EvansTechnical Leadership & Innovations Office, Jhpiego/USA, Baltimore, Maryland, USA.
Sue FawcusDepartment of Obstetrics and Gynaecology, University of Cape Town, Rondebosch, South Africa.
Hadiza S GaladanciDepartment of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital, Kano, Nigeria.
Diem-Tuyet Thi HoangObstetrics and Gynecology, Hung Vuong Hospital, Ho Chi Minh, Viet Nam.
G Justus HofmeyrDepartment of Obstetrics and Gynaecology, University of Botswana, Gaborone, Botswana.
Caroline HomerBurnet Institute, Melbourne, Victoria, Australia.
Ayodele G LewisAmherst College, Amherst, Massachusetts, USA.
Tippawan LiabsuetrakulDepartment of Epidemiology, Prince of Songkla University, Hat Yai, Thailand.ORCID 0000-0001-7687-5629
Pisake LumbiganonDepartment of Obstetrics and Gynaecology, Khon Kaen University, Khon Kaen, Thailand.
Elliott K MainDepartment of Obstetrics & Gynecology-Maternal Fetal Medicine, Stanford University, Stanford, California, USA.
Judith MauaLiverpool School of Tropical Medicine, Nairobi, Kenya.
Francis G MuriithiInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-2314-5611
Ashraf Fawzy NabhanDepartment of Obstetrics & Gynecology, Ain Shams University Faculty of Medicine, Cairo, Egypt.ORCID 0000-0003-4572-2210
Inês NunesDepartment of Obstetrics and Gynaecology, Gaia/ Espinho Local Health Unit, Vila Nova de Gaia, Portugal.
Vanesa OrtegaDepartment of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Thuan N Q PhanDepartment of Women's and Children's Health, University of Liverpool, Liverpool, UK.ORCID 0000-0002-7166-8345
Zahida P QureshiUniversity of Nairobi Department of Obstetrics and Gynecology, Nairobi, Kenya.
Claudio SosaWoman and Reproduction Health Unit at Maternal Health at the Latin American Center of Perinatology (CLAP/WR), Pan American Health Organization, Montevideo, District of Columbia, USA.
John VaralloWomen's Health, Global Surgery Foundation, Washington, District of Columbia, USA.
Andrew D WeeksDepartment of Women's and Children's Health, University of Liverpool, Liverpool, UK.
Mariana WidmerUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.
Olufemi T OladapoUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.
Ioannis GallosUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.
Arri CoomarasamyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Suellen MillerBixby Center for Global reproductive Health, University of California San Francisco, San Francisco, California, USA.
Fernando AlthabeUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

objectiveThere are no globally agreed on strategies on early detection and first response management of postpartum haemorrhage (PPH) during and after caesarean birth. Our study aimed to develop an international expert's consensus on evidence-based approaches for early detection and obstetric first response management of PPH intraoperatively and postoperatively in caesarean birth.

designSystematic review and three-stage modified Delphi expert consensus.

settingInternational. POPULATION: Panel of 22 global experts in PPH with diverse backgrounds, and gender, professional and geographic balance. OUTCOME MEASURES: Agreement or disagreement on strategies for early detection and first response management of PPH at caesarean birth.

resultsExperts agreed that the same PPH definition should apply to both vaginal and caesarean birth. For the intraoperative phase, the experts agreed that early detection should be accomplished via quantitative blood loss measurement, complemented by monitoring the woman's haemodynamic status; and that first response should be triggered once the woman loses at least 500 mL of blood with continued bleeding or when she exhibits clinical signs of haemodynamic instability, whichever occurs first. For the first response, experts agreed on immediate administration of uterotonics and tranexamic acid, examination to determine aetiology and rapid initiation of cause-specific responses. In the postoperative phase, the experts agreed that caesarean birth-related PPH should be detected primarily via frequently monitoring the woman's haemodynamic status and clinical signs and symptoms of internal bleeding, supplemented by cumulative blood loss assessment performed quantitatively or by visual estimation. Postoperative first response was determined to require an individualised approach.

conclusionThese agreed on proposed approaches could help improve the detection of PPH in the intraoperative and postoperative phases of caesarean birth and the first response management of intraoperative PPH. Determining how best to implement these strategies is a critical next step.

Indexed as

Cesarean SectionConsensusDelphi TechniquePostpartum HemorrhageEarly DiagnosisFemaleHumansPregnancyTranexamic AcidTranexamic Acidclinical decision-makingmaternal medicineobstetricspostpartum periodsystematic review

Identifiers

PMID38719306
PMCPMC11086283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.