Evidence map›Paper›PMID 38718895›Full record

ArticleJournal of advanced research2025

Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging.

Siyi Zhou, Zeming Li, Xinzhu Li, Yuanli Ye, Mengyue Wang, Jingwei Jiang, Lihe Tao, Yan Wang, Chen-Tsen Tung, Yongji Chung and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
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  16. Zoological research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Siyi ZhouKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 202119021085@stu.cqu.edu.cn.
Zeming LiKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 202219021036@stu.cqu.edu.cn.
Xinzhu LiKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 20221901001z@stu.cqu.edu.cn.
Yuanli YeKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 202319021075T@stu.cqu.edu.cn.
Mengyue WangKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: Wmy2017@cqu.edu.cn.
Jingwei JiangKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 20201901033@stu.cqu.edu.cn.
Lihe TaoZhejiang Keyikaijian Bioengineering Co., Ltd, Beijing 100191, China. Electronic address: tlhmichael@dermaheal.com.cn.
Yan WangZhejiang Keyikaijian Bioengineering Co., Ltd, Beijing 100191, China. Electronic address: wangyan@dermaheal.com.cn.
Chen-Tsen TungZhejiang Keyikaijian Bioengineering Co., Ltd, Beijing 100191, China. Electronic address: r_t1969@163.com.
Yongji ChungCaregen Co., Ltd, Gyeonggi-do 14119, Korea. Electronic address: chung@caregen.co.kr.
Eunmi KimCaregen Co., Ltd, Gyeonggi-do 14119, Korea. Electronic address: dmsal@caregen.co.kr.
Xinyu ShenKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 202219131160@stu.cqu.edu.cn.
Xuegang XuDepartment of Dermatology, The First Hospital of China Medical University NHC Key Laboratory of Immunodermatology (China Medical University), Key Laboratory of Immunodermatology (China Medical University), Shenyang, Liaoning Province 110001, China. Electronic address: xuxuegang2749290@163.com.
Xiao XiangKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: xiaoxiang_bioeng@cqu.edu.cn.
Qiaoli XieKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: qiaolixie@cqu.edu.cn.
Jinwei ZhangKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: skinzjw@163.com.
Wang WuKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: wwang@cqu.edu.cn.
Xia LinKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: 249239625@qq.com.
Cheng-Ming ChuongDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: cmchuong@usc.edu.
Mingxing LeiKey Laboratory of Biorheological Science and Technology of Ministry of Education & 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: mingxing@cqu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTissues maintain their function through interaction with microenvironment. During aging, both hair follicles and blood vessels (BV) in skin undergo degenerative changes. However, it is elusive whether the changes are due to intrinsic aging changes in hair follicles or blood vessels respectively, or their interactions.

objectiveTo explore how hair follicles and blood vessels interact to regulate angiogenesis and hair regeneration during aging.

methodsSingle-cell RNA-sequencing (scRNA-seq) analyses were used to identify the declined ability of dermal papilla (DP) and endothelial cells (ECs) during aging. CellChat and CellCall were performed to investigate interaction between DP and ECs. Single-cell metabolism (scMetabolism) analysis and iPATH were applied to analyze downstream metabolites in DP and ECs. Hair-plucking model and mouse cell organoid model were used for functional studies.

resultsDuring aging, distance and interaction between DP and ECs are decreased. DP interacts with ECs, with decreased EDN1-EDNRA signaling from ECs to DP and CTF1-IL6ST signaling from DP to ECs during aging. ECs-secreted EDN1 binds to DP-expressed EDNRA which enhances Taurine (TA) metabolism to promote hair regeneration. DP-emitted CTF1 binds to ECs-expressed IL6ST which activates alpha-linolenic acid (ALA) metabolism to promote angiogenesis. Activated EDN1-EDNRA-TA signaling promotes hair regeneration in aged mouse skin and in organoid cultures, and increased CTF1-IL6ST-ALA signaling also promotes angiogenesis in aged mouse skin and organoid cultures.

conclusionsOur finding reveals reciprocal interactions between ECs and DP. ECs releases EDN1 sensed by DP to activate TA metabolism which induces hair regeneration, while DP emits CTF1 signal received by ECs to enhance ALA metabolism which promotes angiogenesis. Our study provides new insights into mutualistic cellular crosstalk between hair follicles and blood vessels, and identifies novel signaling contributing to the interactions of hair follicles and blood vessels in normal and aged skin.

Indexed as

AgingDermisEndothelial CellsHairHair FollicleNeovascularization, PhysiologicRegenerationAngiogenesisAnimalsCell CommunicationHumansMiceSignal TransductionSingle-Cell AnalysisAgingAngiogenesisCell interactionHair regenerationMetabolismMutualism

Identifiers

PMID38718895
PMCPMC11976415

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.