Evidence map›Paper›PMID 38718542›Full record

ReviewCurrent opinion in microbiology2024

Co-ordinated assembly of the multilayered cell envelope of Gram-negative bacteria.

Elayne M Fivenson, Laurent Dubois, Thomas G Bernhardt

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. LPS in gram-negative bacterial growth and physiology: outside but fully integrated.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
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  6. Clinical application of MALDI-TOF MS for direct and rapid pathogen identification: a comprehensive review focusing on bloodstream infections and sterile body fluids.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  7. Article
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  9. Negamycin: Nature's Forgotten Antibiotic.ACS infectious diseases · 2026
    Review
  10. Article
  11. Interactions ofInternational journal of molecular sciences · 2025
    Article
  12. Review
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  15. Article
  16. Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Bacterial peptidoglycan as a living polymer.Current opinion in chemical biology · 2025
    Review
  18. Frontiers in microbiology · 2025
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elayne M FivensonDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, United States.
Laurent DuboisDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, United States.
Thomas G BernhardtDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, United States; Howard Hughes Medical Institute, Boston, United States. Electronic address: thomas_bernhardt@hms.harvard.edu.

Funding

Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
NIAID NIH HHS R01 AI083365
6 · The paper itself

Abstract

Bacteria surround themselves with complex cell envelopes to maintain their integrity and protect against external insults. The envelope of Gram-negative organisms is multilayered, with two membranes sandwiching the periplasmic space that contains the peptidoglycan cell wall. Understanding how this complicated surface architecture is assembled during cell growth and division is a major fundamental problem in microbiology. Additionally, because the envelope is an important antibiotic target and determinant of intrinsic antibiotic resistance, understanding the mechanisms governing its assembly is relevant to therapeutic development. In the last several decades, most of the factors required to build the Gram-negative envelope have been identified. However, surprisingly, little is known about how the biogenesis of the different cell surface layers is co-ordinated. Here, we provide an overview of recent work that is beginning to uncover the links connecting the different envelope biosynthetic pathways and assembly machines to ensure uniform envelope growth.

Indexed as

Cell MembraneCell WallGram-Negative BacteriaPeptidoglycanBacterial ProteinsBacterial ProteinsPeptidoglycan

Identifiers

PMID38718542
PMCPMC11695049

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.