Evidence map›Paper›PMID 38718313›Full record

ArticleNeurology2024

Prevalence and Risk Factors of Distal Symmetric Polyneuropathy Among Predominantly Non-Hispanic Black, Low-Income Patients.

Melissa A Elafros, Alexanndra Brown, Huda Marcus, Thair Dawood, Ghassan I Bachuwa, Mousumi Banerjee, Peter J Winch, Michelle Kvalsund, Eva L Feldman, Lesli E Skolarus and 1 more

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melissa A ElafrosFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.ORCID 0000-0002-4511-201X
Alexanndra BrownFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Huda MarcusFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Thair DawoodFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Ghassan I BachuwaFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Mousumi BanerjeeFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Peter J WinchFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Michelle KvalsundFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.
Eva L FeldmanFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.ORCID 0000-0002-9162-2694
Lesli E SkolarusFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.ORCID 0000-0002-3088-9838
Brian C CallaghanFrom the Departments of Neurology (M.A.E., A.B., E.L.F., B.C.C.) and Biostatistics (M.B.), University of Michigan, Ann Arbor; Department of Internal Medicine (H.M., T.D., G.I.B.), Hurley Medical Center, Flint, MI; Department of Medicine (H.M., T.D., G.I.B.), Michigan State University, East Lansing; Department of International Health (P.J.W.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Neurology (M.K.), University of Rochester, NY; Department of Internal Medicine (M.K.), University of Zambia, Lusaka; and Department of Neurology (L.E.S.), Northwestern University, Chicago, IL.ORCID 0000-0002-8885-6748

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Community Health and Neuropathy: Nutritional and Environmental Links in Zambia (CHANNELZ)K23NS112463 · NINDS · UNIVERSITY OF ROCHESTER · PI KVALSUND, MICHELLE POWELL · 2020 to 2024
$925k
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NINDS NIH HHS K23 NS112463
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDistal symmetric polyneuropathy (DSP) is a disabling, often painful condition associated with falls and reduced quality of life. Non-Hispanic Black people and people with low income are underrepresented in existing DSP studies; therefore, it is unknown whether data accurately reflect the prevalence, risk factors, and burden of disease in these populations.

methodsPatients older than 40 years presenting to an outpatient internal medicine clinic predominantly serving Medicaid patients in Flint, Michigan, were enrolled in a cross-sectional study. Demographics, clinical characteristics, including medication use, anthropomorphic measurements, fasting lipids, and hemoglobin A1c were collected. DSP was defined using the modified Toronto Clinical Neuropathy Score (mTCNS). Multivariable logistic regression was performed to model DSP and undiagnosed DSP as a function of potential risk factors age, metabolic syndrome, and race. DSP burden was measured using Peripheral Neuropathy Quality of Life Instrument-97.

resultsTwo hundred participants were enrolled, and 169 (85%) completed all data collection. The population was 55% female of mean age (SD) 58.2 years (10.4) and 69% non-Hispanic Black. Among the population, 50% had diabetes, 67% had metabolic syndrome, and 47% had a household income <$20,000. DSP was present in 73% of the population, of which 75% were previously undiagnosed. Neuropathic pain was documented in 57% of participants with DSP. DSP based on mTCNS criteria was associated with older age (odds ratio [OR] 1.1 [95% confidence interval (CI) 1.03-1.2]) and metabolic syndrome (OR 4.4 [1.1-18.1]). Non-Hispanic Black participants had lower odds of DSP (OR 0.1 [0.01-0.4]) than non-Hispanic White and Hispanic participants. DSP burden was high, including increased pain, health-related worry, and poorer quality of life (all DISCUSSION: DSP is extremely common and often underrecognized in this predominantly non-Hispanic Black, low-income population and leads to substantial disease burden. Metabolic syndrome is a highly prevalent, modifiable risk factor in this population that should be managed to lower DSP prevalence.

Indexed as

Black or African AmericanPovertyAdultAgedCross-Sectional StudiesFemaleHispanic or LatinoHumansMaleMichiganMiddle AgedPolyneuropathiesPrevalenceQuality of LifeRisk FactorsWhite

Identifiers

PMID38718313
PMCPMC11175633

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